Polymeric Emulsion Technology Applied to Tretinoin

April 2019 | Volume 18 | Issue 4 | Supplement Individual Articles | 148 | Copyright © April 2019

Leon H. Kircik MD,a Zoe D. Draelos MD,b Diane S. Berson MDc

School of Medicine at Mount Sinai, New York, NY; Indiana School of Medicine, Indianapolis, IN; Physicians Skin Care, PLLC, Louisville, KY; DermResearch, PLLC, Louisville, KY; Skin Sciences, PLLC, Louisville, KY BDermatology Consulting Services, PLLC, High Point, NC cDepartment of Dermatology, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY

Figure4Ban effective skin barrier by reducing epidermal water loss and improving skin hydration. Skin hydration and barrier protection of the lotion were assessed through corneometry and transepidermal water loss (TEWL) in 30 female healthy volunteers (aged 35-65 years) over 24 hours, using the test material applied to the volar forearm, with an untreated site serving as a control. Measurements using Tewameter® and Corneometer® were taken at baseline, 15 and 30 minutes, and 1, 2, 3, 8, and 24 hours post-application. In addition, at the 8-hour study period 15 subjects applied the test material to the right side of their face and completed a customer perception evaluation of the novel formulation. Adverse events (AEs) were noted throughout and irritation assessed at pre- and post-application. There were no AEs or skin irritation reported throughout the study. At baseline, mean corneometry scores were 29.2 ± 2.4 and 28.1 ± 2.7 units (test material and untreated control, respectively). There was an immediate improvement in water content that was maintained throughout the study with the test material. After 15 minutes, the mean score had increased to 59.4 ± 4.3 units (Figure 2). There was no improvement at the control site and