Reports generally described improvements in hand dermatitis on dupilumab. Various types of hand dermatitis were described in articles including allergic contact dermatitis, atopic hand eczema, and dyshidrotic eczema. Cases where dupilumab was chosen for this indication involved severe baseline disease or recalcitrant cases (Table 1). The largest study included 38 patients with hand dermatitis of various etiologies. It reported that the majority of patients improved in terms of IGA scores, and in subjective reports of pruritus and pain from hand fissures (Table 1).9 Isolated reports also describe successful use of dupilumab for highly recalcitrant hand dermatitis, resulting in improvement in patients who had previously failed multiple treatment modalities including oral immunosuppressants.10
One case series described 6 patients with histories of atopic dermatitis who failed omalizumab and were subsequently trialed on dupilumab, with all 6 patients sustaining improvement. 11 Dupilumab is now being studied in randomized clinical trials for chronic spontaneous urticaria (CSU) and cholinergic urticaria (Table 2).
Small case series reported improvement in patients with prurigo nodularis in terms of subjective itch ratings, and in lesion number and size. In addition, concomitant therapies were able to be weaned (Table 1).
Four case reports describe response of alopecia to dupilumab, which all coincidentally improved in patients receiving dupilumab for atopic dermatitis. A randomized controlled trial is currently underway studying dupilumab for treatment of alopecia areata with and without atopic dermatitis.12
Isolated case reports describe successful use of dupilumab for eosinophilic annular erythema, anogenital pruritus, and bullous pemphigoid (Table I).