Treatment of Arsenic-Induced Bowen’s Disease With Topical 5-Fluorouracil

May 2019 | Volume 18 | Issue 5 | Case Reports | 477 | Copyright © May 2019

Brendon Verhave BS,a Matthew Goldberg MD,b Peter Hashim MD,b Jacob Levitt MDb

aSUNY Upstate Medical University, Syracuse, NY bMount Sinai Health Systems, New York, NY


  1. Martinez, V. D., Becker-Santos, D. D., Vucic, et al. Induction of Human Squamous Cell-Type Carcinomas by Arsenic. J Skin Cancer. 2011;2011:454157.
  2. Rahman, M. M., Chowdhury, U. K., Mukherjee, S. C., et al. Chronic Arsenic Toxicity in Bangladesh and West Bengal, India—A Review and Commentary. J Toxicol Clin Toxicol. 2001;39(7):683-700.
  3. Son, S. B., Song, H. J., Son, S. W. (2008). Successful treatment of palmoplantar arsenical keratosis with a combination of keratolytics and low-dose acitretin. Clin Exp Dermatol. 2008;33(2):202-204.
  4. Haque, R., Mazumder, D. N., Samanta, S., et al. Arsenic in Drinking Water and Skin Lesions: Dose-Response Data from West Bengal, India. Epidemiology. 2003;14(2):174-182.
  5. Khandpur, S., Sharma, V. K. Successful Treatment of Multiple Premalignant and Malignant Lesions in Arsenical Keratosis with a Combination of Acitretin and Intralesional 5-Fluorouracil. J Dermatol. 2003;30(10):730-734.
  6. Yerebakan, O., Ermis, O., Yilmaz, E., et al. Treatment of arsenical keratosis and Bowens disease with acitretin. Int J Dermatol. 2002;41(2):84-87.
  7. Park, J. Y., Rim, J. H., Choe, Y. B., et al. (2002). Arsenic Keratosis and Pigmentation Accompanied by Multiple Bowens Disease and Genitourinary Cancer in a Psoriasis Patient. J Dermatol. 2002;29(7):446-451.
  8. A case of arsenic keratosis in a patient from Newfoundland, Canada. J Am Acad Dermatol. 2015;72(5).
  9. Hodari, K. T., Nanton, J. R., Carroll, C. L., et al. (Adherence in dermatology: A review of the last 20 years. J Dermatol Treat. 2006;17(3):136-142.
  10. Chen, A. C., Martin, A. J., Choy, B., et al. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention. NEJM. 2015;373(17):1618- 1626.
  11. Acitretin: MedlinePlus Drug Information. (n.d.).
  12. Lehmann, P. Bowen’s disease – a review of newer treatment options. Ther Clin Risk Manag. 2008;4:1085-1095.
  13. Kadakia, Kunal C., et al. Randomized controlled trial of acitretin versus placebo in patients at high-risk for basal cell or squamous cell carcinoma of the skin (North Central Cancer Treatment Group Study 969251). Cancer. 2012;118(8):2128–2137.
  14. Bavinck JN, Tieben LM, Van der Woude FJ, et al. Prevention of skin cancer and reduction of keratotic skin lesions during acitretin therapy in renal transplant recipients: a double-blind, placebo-controlled study. J Clin Oncol. 1995;13:1933–1938.
  15. George R, Weightman W, Russ GR, et al. Acitretin for chemoprevention of non-melanoma skin cancers in renal transplant recipients. Australas J Dermatol. 2002;43:269–273.


Brendon Verhave BS