Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation

9. K. Shankar, K. Ghodse, Aurangabadker S, et al. Evidence-based treatment for melasma: expert opinion and a review. Dermatol Ther (Heidelb). 2014;4(2):165–186.10. Deo KS, Dash KN, Sharma YK, Virmani NC, Oberai C. Kojic acid vis-a-vis its combinations with hydroquinone and betamethasone valerate in melasma: a randomized, single blind, comparative study of efficacy and safety. Indian J Dermatol. 2013;58(4):281-5.11. Monteiro RC, Kishore BN, Bhat RM, Sukumar D, Martis J, Ganesh HK. A comparative study of the efficacy of 4% hydroquinone vs 0.75% kojic acid cream in the treatment of facial melasma. Indian J Dermatol. 2013;58(2):157.12. Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, Oros-Ovalle C, Fuentes-Ahumada C, González FJ, Martínez-Ramírez JD, Moncada B. A double- blind, randomized clinical trial of niacinamide 4% versus hydroquinone 4% in the treatment of melasma. Dermatol Res Pract. 2011;2011:379173.13. Rolfe HM. A review of nicotinamide: treatment of skin diseases and potential side effects. J Cosmet Dermatol. 2014;13(4):324-8.14. Tse, T. W., & Hui, E. Tranexamic acid: An important adjuvant in the treatment of melasma. J Cosmet Dermatol. 2013;12(1):57-66.15. Byun SY, Chae JB, Na JI, Park KC. Significant improvement in crow’s feet after treatment with Jet-M and a mixed solution of copper–GHK, oligo-hyaluronic acid, rhodiolar extract, tranexamic acid, and beta-glucan (GHR formulation). J Cosmet Laser Ther. 2016;18(5):293–5.16. World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects (1964). Bull. World Health Org. 2001; 79(4): 373-374.17. Lee JH, Park JG, Lim SH, Kim JY, Ahn KY, et al. Localized intradermal microinjection of tranexamic acid for treatment of melisma in Asian patients: a preliminary clinical trial. Dermatol Surg. 2006;32:626-631.18. Maeda K, Naganuma M. Topical trans-4-aminomethyl cyclohexanecarboxylic acid prevents ultraviolet radiation-induced pigmentation. J Photochem Photobiol B. 1998;47:136-141.19. Kondou S, Okada Y, Tomita Y. Clinical study of effect of tranexamic acid emulsion on melasma and freckles. Skin Res. 2007;6:309-315.20. Na JI, Choi SY, Yang SH, Choi HR, Kang HY, et al. Effect of tranexamic acid on melasma: a clinical trial with histological evaluation. J Eur Acad Dermatol Venereol. 2013;27:1035-1039.21. Nijo T. Treatment of melasma with tranexamic acid. Clin Res. 1979;13:3129- 3131.22. Shital P. and Khushboo M. Tranexamic acid in melasma: a review. J Pigment Disord. 2015;2(12):1-4.23. Starner RJ, McClelland L, Abdel?Malek Z, Fricke A, Scott G. PGE(2) is a UVR?inducible autocrine factor for human melanocytes that stimulates tyrosinase activation. Exp Dermatol. 2010;19:682-4.24. Kang-Rotondo CH1, Miller CC, Morrison AR, Pentland AP. Enhanced keratinocyte prostaglandin synthesis after UV injury is due to increased phospholipase activity. Am J Physiol. 1993;C396-401.