Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation
May 2019 | Volume 18 | Issue 5 | Original Article | 454 | Copyright © May 2019
Seemal Desai MD,a,b Eloisa Ayres MD,c Hana Bak MD,d,e Megan Manco MS,f Stephen Lynch PhD,g Susana Raab MS,g Ana Du BS,g DesTenee Green BS,g Cezary Skobowiat PhD,g Janet Wangari-Talbot PhD,g Qian Zheng MD PhDg
aUniversity of Texas Southwestern Medical Center, Dallas, TX bInnovative Dermatology, Plano, TX cEZSkin Dermatologia, Niterói, Rio de Janeiro, Brazil dCheongdam-Hana Dermatology, Seoul, Korea eYonsei University Wonju College of Medicine, Wonju, Korea fSkinceuticals, New York, NY gL’Oréal Research and Innovation, Clark, NJ
Similar results were observed for PIH. As early as 4 weeks, the melanin index of the lesional PIH skin significantly decreased, which continued through week 12. The perilesional normal skin (control site) also demonstrated a significant decrease in skin color with treatment at weeks 4 and 8. The decrease in MI was significantly greater in lesional PIH skin as compared to perilesional normal skin on week 2 (P=0.048), week 8 (P=0.002), and week 12 (P=0.014). The data demonstrates that the facial serum has greater efficacy on lesional PIH skin as compared to unaffected, normal skin.The erythema index (EI) showed no significant change at most time points for both melasma and PIH. A significant decrease in EI scores was observed at week 8 for both the lesional melasma skin and perilesional normal skin, and week 8 for the lesional PIH skin, respectively (data not shown). However, no significant changes in EI were achieved in lesional skin as compared to perilesional normal skin for both melasma and PIH.Self-Assessment Questionnaires
Overall satisfaction with the serum’s aesthetics and efficacy were significant at all time points (data not shown).Safety and Local intolerances
Local cutaneous tolerability was acceptable (data not shown). Minor transient effects such as erythema (2/55), itching (1/55),pruritis (1/55), redness (1/55), or stinging (1/55) were observed during the course of the study. Local intolerances were transient and quickly resolved after the product application. From the dermatologist’s observation and conclusion, the product was considered to have very good tolerability and cutaneous acceptability.
In Vitro Study Results
TXA Inhibition of PGE2 Induced Melanogenesis 30nM PGE2 significantly stimulated melanin production in human epidermal melanocytes (HEM) compared to control cells (P=0.02; Figure 2). TXA alone showed no effect on melanin content of HEM. 50 μM and 100 μM TXA treatment of PGE2- stimulated melanocytes demonstrated a significant decrease in melanin content (P=0.046 and P=0.023, respectively. There was no significant difference between 50 μM TXA and 100 μM TXA.