A Double-Blind Randomized Pilot Study Evaluating the Safety and Efficacy of Topical MEP in the Facial Appearance Improvement of Estrogen Deficient Females
November 2018 | Volume 17 | Issue 11 | Original Article | 1186 | Copyright © November 2018
Zoe Diana Draelos MD
Dermatology Consulting Services, PLLC, High Point, NC
This vehicle-controlled double-blinded study demonstrated the safety, tolerability, and efficacy of MEP, a topical soft estrogen cosmeceutical for the treatment of EDS and the improvement of facial appearance without systemic effects. Investigator noted improvements in facial skin dryness, laxity, and dullness and subject noted improvements in facial fine lines and atrophy after 14 weeks of twice daily application are consistent with the histologic observation of increased estrogen receptors. Absent any other known mode of action of MEP, it is presumably the estrogen receptor binding activity of MEP that accounted for these findings. This novel ingredient uniquely addresses appearance issues common in estrogen deficient females.
Dr. Draelos received a grant from Ferndale Pharma Group to conduct this research.
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