Multi-Center, Double-Blind, Vehicle-Controlled Clinical Trial of an Alpha and Beta Defensin-Containing Anti-Aging Skin Care Regimen With Clinical, Histopathologic, Immunohistochemical, Photographic, and Ultrasound Evaluation
Amy Taub MD,a Vivian Bucay MD,b Gregory Keller MD,c Jay Williams PhD,c and Darius Mehregan MDd
aAdvanced Dermatology/Skinfo, Lincolnshire, IL; Northwestern University Medical School, Department of Dermatology, Chicago, IL bBucay Center for Dermatology and Aesthetics, San Antonio, TX cGregory Keller Plastic Surgery, Santa Barbara, CA dWayne State University, Monroe, MI
based in Griffiths scale (clinical evaluation by investigators).22 A punch biopsy of post-auricular skin of 7 randomly chosen study participants (3 and 4 from PG and the FFG groups, respectively, at Sites 1 and 2). Biopsies were analyzed by H and E histopathology and immunohistochemistry analysis for Ki67 marker by a board certified dermatopathologist (Mehregan). Skin of 15 participants (Site 3) underwent non-invasive multi-parameter skin testing using DermaLab® SkinLab Combo Suite (Cortex Technologies, Denmark). The testing included high-resolution skin ultrasound (dermis), the measurements of transepidermal water loss (TEWL), skin elasticity, skin color (melanin), and skin hydration. In addition, individual skin health scores (evenness, pores, and oiliness) for the same 15 study participants were calculated using 3-dimensional
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