Efficacy and Safety of Apremilast in Systemic- and Biologic-Naive Patients With Moderate Plaque Psoriasis: 52-Week Results of UNVEIL

February 2018 | Volume 17 | Issue 2 | Original Article | 221 | Copyright © February 2018

Linda Stein Gold MD,a Jerry Bagel MD,b Mark Lebwohl MD,c J. Mark Jackson MD,d Rongdean Chen PhD,e Joana Goncalves MD,e Eugenia Levi PharmD,e Kristina Callis Duffin MD MSf

aHenry Ford Health System, West Bloomfield, MI bPsoriasis Treatment Center of Central New Jersey, East Windsor, NJ cIcahn School of Medicine at Mount Sinai, New York, NY dUniversity of Louisville, Forefront Dermatology, Louisville, KY eCelgene Corporation, Summit, NJ fUniversity of Utah, Salt Lake City, UT

treatment have not yet been described exclusively in patients with moderate disease. However, results from other longer-term studies in patients with moderate to severe psoriasis are consistent with findings from the current 52-week study.23,24


In UNVEIL, improvements in signs and symptoms of moderate plaque psoriasis (BSA 5% to 10%) achieved with 16 weeks of apremilast treatment10 were sustained or displayed continued improvement with treatment that extended up to 52 weeks in systemic- and biologic-naive patients. Apremilast had a significantly positive and sustained impact on QOL and treatment satisfaction, with few patients discontinuing longer-term treatment because of AEs. The open-label apremilast treatment phase further demonstrated that apremilast is a systemic treatment with a favorable risk-benefit profile that may be appropriate for patients with moderate plaque psoriasis.


Linda Stein Gold: Celgene Corporation, LEO Pharma, Novartis, Pfizer, and Stiefel/GlaxoSmithKline–investigator and/or consultant.Jerry Bagel: AbbVie, Amgen, Boehringer Ingelheim, Celgene Corporation, Janssen, LEO Pharma, Eli Lilly, Novartis, Pfizer, and Valeant–advisory board member, speaker, consultant, and/or research support; Sun Pharma–consultant.Mark Lebwohl: Boehringer Ingelheim, Celgene Corporation, Eli Lilly, Janssen/Johnson & Johnson, Kadmon, MedImmune/AstraZeneca, Novartis, Pfizer, and ViDac–research support through Icahn School of Medicine at Mount Sinai.J. Mark Jackson: AbbVie, Amgen, Celgene Corporation, Dermira, Galderma, Genentech, Janssen, Lilly, Medimetriks, Merck, Novartis, Pfizer, Promius, and TopMD–research, honoraria, consulting, and/or other support.Rongdean Chen: Celgene Corporation–employment at the time of study conduct.Joana Goncalves: Celgene Corporation–employment.Eugenia Levi: Celgene Corporation–employment.Kristina Callis Duffin: AbbVie, Amgen, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene Corporation, Centocor/Janssen, Eli Lilly, Novartis, Pfizer, Regeneron, Stiefel, and XenoPort–consultant, steering committee member, advisory board member, has received grants, and/or has received honoraria.


The authors acknowledge financial support for this study from Celgene Corporation. The authors received editorial support in the preparation of this manuscript from Karen Dougherty, PhD, and Amy Shaberman, PhD, of Peloton Advantage, LLC, Parsippany, NJ, USA, funded by Celgene Corporation, Summit, NJ, USA. The authors, however, directed and are fully responsible for all content and editorial decisions for this manuscript. All authors had full access to all of the data, and data are available upon request.


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Linda Stein Gold MD LSTEIN1@hfhs.org