Secukinumab: A Review of Safety and Efficacy in Psoriatic Arthritis
August 2017 | Volume 16 | Issue 8 | Supplement Individual Articles | 118 | Copyright © August 2017
Peter W. Hashim MD MHS,a Kim A. Papp MD PHD,b Philip J. Mease MDc
aThe Icahn School of Medicine at Mount Sinai, Department of Dermatology, New York, NY bK. Papp Clinical Research and Probity Medical Research, Waterloo, Ontario, Canada cSwedish Hospital Clinical Research Division, Swedish Medical Center, and University of Washington School of Medicine, Seattle, WA
improvements have been observed in both anti–TNF-naïve and anti–TNF-exposed subjects, although anti-TNF-naïve patients experienced greater benefit. Additional phase III studies, including FUTURE-3 (ClinicalTrials.gov/NCT01989468), FUTURE-4 (ClinicalTrials.gov/NCT02294227), and FUTURE-5 (ClinicalTrials.gov/NCT02404350), are planned in order to further assess dosing regimens and patient outcomes. Given the increasingly recognized role of IL-17A in PsA, secukinumab represents an important therapeutic agent in treatment algorithms.
Dr. Papp has been a consultant and speaker and has served on steering committees and advisory boards and has received research grants from Novartis. Dr. Mease has served as a consultant and speaker and has received research grants from Novartis. Dr. Hashim has no conflicts.
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