A Novel Multifactorial Approach to Developing Mild Laundry Detergents and Assessing Their Relative Mildness

December 2017 | Volume 16 | Issue 12 | Original Article | 1235 | Copyright © December 2017

Joseph F. Fowler Jr. MD,a Matthew J. Zirwas MD,b Lisa Napolitano BS,c Meghan Russell BS,c and Janet Coope-Epstein PhDc

aUniversity of Louisville and Division of Occupational Medicine at the University of Kentucky, Louisville, KY bMount Carmel East and West Hospitals, Columbus, OH; Private Practice, Columbus, OH cThe Sun Products Corporation, a Henkel Company; Stamford, CT

Figure 1Figure 2extrapolate these test results to potential SC irritancy.Therefore, the DPD formula is expected to cause the least damage to the SC proteins, when compared with other mild detergents.


The results of the CSM test showed a lower degree of staining after exposure to DPD formula compared to other mild detergents. The 100-CIM value is proportionately related to the degree of SC damage and subsequent staining. Therefore, DPD formula was shown to cause the lowest level of SC damage compared to other mild laundry detergents. In contrast, Product 11 was associated with the greatest amount of SC damage. With the exception of Product 4, these differences compared to DPD formula were found to be statistically signi cant.


As Figure 4 shows, the EpiDermTM Skin Model released a lower level of cytokine IL-1α after exposure to DPD formula when compared to the other mild detergents. Additionally, there was a marked difference between the amounts of cytokine IL-1α released after exposure to DPD formula compared to Product 11. With the exceptions of Products 1, 2, 4, and 5, the difference between the samples were found to be statistically significant. Therefore, DPD formula was shown to induce a lower