Zoe Diana Draelos MD,a Tatiana Kononov BS MBA,b and Theresa Fox BSb
aDermatology Consulting Services, High Point, NC bRevision Skincare, Irving, TX
Overall, the results of this single-center study indicate that the use of this peptide treatment serum and supporting regimen was effective in improving signs of facial skin aging, especially expression lines such as crow’s feet and forehead lines, when compared to baseline results and used over the course of 14 weeks by women with mild to moderate photoaging. There was a statistically significant difference in skin appearance from the lower eyelids to the hairline after 12 weeks of peptide treatment serum application as assessed by both the investigator and by the subjects when compared to baseline results. Of special interest are the investigator’s results of eye lines and eye wrinkles both at rest and at maximum smile when compared to baseline results. The investigator found a statistically significant reduction in these parameters. The investigator’s findings are supported by the before and after photos of the subjects with 2 examples illustrated in Figures 3 and 4. Both the peptide treatment serum and eye cream were applied to this area, however, because the eye cream was for moisturizing purposes only and contained no anti-aging ingredients, it is believed that these results can be entirely attributed to the efficacy of the peptide serum. This evidence supports the hypothesis that combining various neurotransmitter inhibiting and cell signaling peptides, such as acetyl hexapeptide-8 and DDBD, with known topical benefits, into a treatment product will reduce the signs of aging caused by repeated facial expressions. In addition to the results in the eye area, there was a significant difference in skin appearance over the entire face after 12 weeks of application of the peptide treatment serum and 14 weeks of the supporting
regimen when compared to baseline results as assessed by the investigator. A number of attributes significantly improved over the course of the study, both at rest and maximum smile when compared to baseline results. Lastly, subjects rated the regimen as effective and aesthetically pleasing and noted that they would purchase the product. The product regimen took 8 weeks to produce visual results in the subjects’ opinion, but these positive results continued once obtained.
Worsening of erythema and desquamation was reported by subjects at 2 weeks, but this resolved by the end of the study and was not supported by the investigator’s findings. No adverse events were reported.
A limitation of this study includes the lack of a control product.
A 14-week single-center clinical usage study was conducted to test a facial peptide treatment serum and supporting regimen in 29 women with mild to moderately photodamaged skin. At week 14, an expert investigator found statistically significant improvement in facial lines, facial wrinkles, eye lines, and eye wrinkles at rest when compared to baseline results. In addition, there was continued highly statistically significant improvement in smoothness, softness, firmness, radiance, luminosity, and overall appearance at rest when compared to baseline results. The expert investigator also found statistically significant improvement at week 14 in facial lines, eye lines, and eye wrinkles when compared to baseline results at maximum smile. The test regimen was well-perceived by the subjects for efficacy
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