Resident Rounds: Part II - Primary Immunodeficiencies

December 2015 | Volume 14 | Issue 12 | Features | 1480 | Copyright © December 2015

Jeffrey F. Scott MD, Danyelle Dawes MD, and Kevin D. Cooper MD

Department of Dermatology, University Hospitals Case Medical Center, Cleveland, OH

Abstract
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INTRODUCTION

The primary immunodeficiencies (PIDs) can be classified by their effects on innate and adaptive immunity, and must be distinguished from secondary immunodeficiencies, which are commonly caused by medications, infections, and malnutrition. PIDs commonly present with recurrent infections and cutaneous manifestations, but can also result in autoimmune disease, allergy, and malignancy due to immune dysregulation.1,2
table 1