Reproducible Novel Transcriptional Differences Between Psoriatic Lesional and Non-Lesional Skin Show Increased Inflammation and Metabolism
August 2015 | Volume 14 | Issue 8 | Original Article | 794 | Copyright © August 2015
Daniel J. Aires MD JD,a Graham Rockwell PhD,b Alan Menter MD,c Colton Nielson,d Jo Wick PhD,e Stephanie Sedivy MD,f Ossamma Tawfik MD PhD,g Anne Bowcock PhD,h and Animesh A. Sinha MD PhDi
aDivision of Dermatology, University of Kansas Medical Center, Kansas City, KS
bDepartment of Bioinformatics, Boston University, Boston, MA
cDept. of Dermatology, Baylor University Medical Center, Dallas, TX
dUniversity of Kansas School of Medicine, Kansas City, KS
eDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, KS
fDermatopathology, Physician’s Reference Laboratory, Overland Park, KS
gDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS
hDivision of Human Genetics, Washington University, St. Louis, MO
iDepartment of Dermatology, University at Buffalo, Buffalo, NY
OBJECTIVE: To reproducibly assess single-gene transcriptional changes in psoriatic skin.
METHODS: We evaluated 210 top candidate genes from a first psoriasis study group (population 1), and then confirmed differential expression in a second independent psoriasis study group (population 2).
RESULTS: One hundred and thirty-eight differentially expressed genes were replicated in the 2 studies, of which 57 have not previously been reported as associated with psoriasis. This is significantly greater than the 10 expected false positives. Lesional skin vs uninvolved areas showed inflammatory and cell regulation changes.
CONCLUSION: Previously undescribed psoriasis-associated genes revealed in this study may provide potential future targets for development and assessment of novel therapeutic agents for psoriasis.
J Drugs Dermatol. 2015;14(8):794-800.