Primary Cutaneous T-cell Lymphoma With Aberrant CD-20 Expression
May 2015 | Volume 14 | Issue 5 | Case Reports | 515 | Copyright © May 2015
Chante Karimkhani BA,a Cristina McLaughlin MD,b and Christopher Smith MDc
aColumbia University College of Physicians and Surgeons, New York, NY
bUniPath LLC, Denver, CO
cFlatirons Dermatology, Broomfield, CO
OBSERVATIONS: We present a case of primary cutaneous T-cell lymphoma with aberrant CD20 expression in a 97-year-old male who presented with a 2-year history of pruritic plaques and nodules covering his body. Nodule biopsy demonstrated a dense, atypical dermal T-lymphocytic infiltrate consisting of predominantly large cells exhibiting classic T-cell markers (CD4 and CD3) along with aberrant expression of the B-cell marker CD20 (expressed in late pro-B to mature B cells).
CONCLUSIONS: The patient was tentatively diagnosed with primary cutaneous CD30-negative large T-cell lymphoma with aberrant CD20 co-expression, pending workup to exclude systemic lymphoma with cutaneous involvement. He unfortunately passed away 4 days after the initial dermatologic presentation.
RELEVANCE: The prognostic implications of CD20-positive T-cell lymphoma require further exploration, along with the potential role of CD20 antibody in treatment of this rare malignancy.
J Drugs Dermatol. 2015;14(5):515-516.