Time to Consider Psoriasis an Autoimmune Disorder?

February 2015 | Volume 14 | Issue 2 | Editorials | 112 | Copyright © February 2015

Jashin J. Wu MDa and Young M. Choi BS

aDepartment of Dermatology, Kaiser Permanente Medical Center, Los Angeles, CA
bDavid Geffen School of Medicine at UCLA, Los Angeles, CA




  1. Wu JJ, Nguyen TU, Poon KT, et al. The association of psoriasis with autoimmune disorders. J Am Acad Dermatol 2012;67:924-30.
  2. Makredes M, Robinson D Jr, Bala M, et al. The burden of autoimmune disease: a comparison of prevalence ratios in patients with psoriatic arthritis and psoriasis. J Am Acad Dermatol 2009;61:405-10.
  3. Zenewicz LA, Abraham C, Flavell RA, et al. Unraveling the genetics of autoimmunity. Cell 2010;140:791–7.
  4. Invernizzi P , Gershwin ME. The genetics of human autoimmune disease. J Autoimmun 2009;33:290–9.
  5. Criswell LA, Pfeiffer KA, Lum RF, et al. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Am J Hum Genet 2005;76:561-71.
  6. Ellinghaus D, Ellinghaus E, Nair RP, et al. Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. American journal of human genetics. 2012 Apr 6;90(4):636-47.
  7. Jostins L, Ripke S, Weersma RK, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012 Nov 1;491(7422):119-24.
  8. Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of psoriasis. Nature 2007;445(7130):866-873.
  9. Ganguly D, Chamilos G, Lande R, et al. Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med 2009;206(9):1983-1994.
  10. Davidson A, Diamond B. Autoimmune diseases. N Engl J Med 2001;345(5):340-350.