Effect of Skin Barrier Emulsion Cream vs a Conventional Moisturizer on Transepidermal Water Loss and Corneometry in Atopic Dermatitis: A Pilot Study
December 2014 | Volume 13 | Issue 12 | Original Article | 1482 | Copyright © December 2014
Leon H. Kircik MD
Icahn School of Medicine at Mount Sinai, New York, NY; Indiana University School of Medicine, Indianapolis, IN;
Physicians Skin Care, PLLC, Louisville, KY
The repair and maintenance of the epidermal barrier is of the utmost importance in the treatment of atopic dermatitis (AD). While barrier
creams and emollients are considered to be a foundation of AD therapy, there is little comparative data between various product options.
This was a pilot study with a small sample size to investigate the use of skin barrier emulsion cream vs a commonly used moisturizing
lotion to improve the epidermal barrier in subjects with atopic dermatitis. J Drugs Dermatol.
It is now well recognized that the epidermal barrier serves
not only to prevent the entry of exogenous factors such as
irritants or allergens, but also to mediate disease. Although
it was long known that dysfunction of the barrier may directly
contribute to atopic dermatitis (AD), most of the evidence now
suggests that there is a significant relationship between epidermal
barrier dysfunction and cutaneous inflammation.