Assessment of Cardiovascular Risk in Patients With Moderate to Severe Plaque Psoriasis
October 2014 | Volume 13 | Issue 10 | Original Article | 1240 | Copyright © October 2014
Hector Fernández-Llaca MD,a Pablo de la Cueva MD,b Jesús Luelmo MD,c Jose Carlos Armario-Hita MD,d
M Luz Samaniego,e and Carmen García-Calvo MDf [Representing the RECOR Study Group.],
aDepartment of Dermatology, Hospital Universitario Marqués de Valdecillas, Santander, Spain
bDepartment of Dermatology, Hospital Universitario Infanta Leonor, Madrid, Spain
cDepartment of Dermatology, Corporació Sanitaria Parc Taulí, Sabadell, Spain
dDepartment of Dermatology, UCG Bloque Quirúrgico, Hospital Universitario de Puerto Real, Universidad de Cádiz, Cádiz, Spain
eStatistical Department, Trial Form Support, Madrid, Spain
fMedical Department, Pfizer Spain, Madrid, Spain
METHODS: A cross-sectional, multicentre study was made of 477 patients, of whom 238 had moderate to severe psoriasis (cases) and 239 were diagnosed with another dermatological disease (controls).
RESULTS: The proportion of patients with intermediate to high 10-year cardiovascular risk using the Framingham equation was significantly higher among psoriasis patients (38.5%; 80/208) than among the controls with other dermatological diseases (23.4%; 50/214, P<.05). No significant differences were observed between the 2 groups with respect to cardiovascular risk using the SCORE risk charts (P=.591). The case group included a greater proportion of obese and morbidly obese patients, as well as patients with higher triglyceride and low density lipoprotein cholesterol levels (P<.05); while high density lipoprotein cholesterol levels were significantly more favorable in patients in the control group (P<.05).
CONCLUSIONS: Cardiovascular risk was greater in patients with moderate to severe psoriasis than in patients with other dermatological conditions, suggesting that early detection and tailored management of risk factors is essential to reducing cardiovascular morbidity in these patients.
J Drugs Dermatol. 2014;13(10):1240-1247.