Resident Rounds. Part III. Case Report: Flagellate Erythema With Dermatographism

January 2014 | Volume 13 | Issue 1 | Feature | 87 | Copyright © 2014

Lindsey A. Brodell MD and Milan Anadkat MD

Washington University in St. Louis, Barnes Jewish Hospital, St. Louis, MO

Abstract

Flagellate erythema occurs following the consumption of raw or undercooked shitake mushrooms, in associated with autoimmune disease, and after bleomycin treatment. A dramatic case of shitake mushroom-induced flagellate erythema is presented, highlighting the presence of dermatographism in this patient.

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INTRODUCTION

Flagellate erythema has been associated with eating raw or undercooked shitake mushrooms (Lentinus edodes), in association with autoimmune diseases such as dermatomyositis,lupus erythematosus, or Still’s Disease, and following bleomycin chemotherapy.

CASE REPORT

A 23 year-old white female presented with a five-day history of a mildly pruritic rash on the upper chest, back, arms, and face (Figure 1a). This occurred 48 hours after ingesting a shrimp and raw shitake mushroom salad. She had no other medical problems. Review of systems was significant for a 24-hour history of mild wheezing. There were no arthralgias or muscle weakness. Physical examination revealed linear streaks of erythema on the ventral wrists, left shoulder, upper chest, and back with violaceous edema of the eyelids and macular erythema of the cheeks. Dermatographism on her back was elicited in the office (Figure 1b). ANA was negative. A three-week tapering course of prednisone led to complete resolution of the rash.

DISCUSSION

Shitake mushrooms, though once primarily consumed in Asian countries, are now the second most common mushrooms ingested worldwide. Lentinan, a protein in the cell wall of these mushrooms, induces shitake dermatitis. Fully cooking the mushroom inactivates this protein through a conformational change preventing the development of flagellate erythema.1

While the pathogenesis is not well understood, lentinan has been shown to increase IL-1 secretion and subsequent vasodilation. 2 Previous case reports emphasize that while koebnerization may explain the flagellate appearance of the rash, dermatographism has not been present. We hypothesize that mast cells transiently activated in the setting of lentinan, release histamine (dermatographism) and a cascade of cytokines that produce the persistent flagellate erythema of shitake dermatitis. The dermatographism is a transient phenomenon not present at the later stage when most patients visit their physician. This would be consistent with the non-specific histopathology (spongiosis, elongated rete ridges, dermal edema, and perivascular mixed cell inflammatory infiltrate) described in shitake dermatitis.3

A careful clinical history is required to confirm a diagnosis of shitake dermatitis in patients who present with flagellate erythema. Transient dermatographism early in the course does not preclude this diagnosis and, in fact, may be a clue to explain the classic flagellate erythema identified in these patients.

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ACKNOWLEDGMENT

Dr. L. Brodell wrote the first draft of this manuscript. Dr. M. Anadkat reviewed and approved the content of the final draft. This case has not been previously published in the literature.

DISCLOSURES

Drs. Brodell and Anadkat have no relevant conflicts of interest.

REFERENCES

  1. Wang, X, Xu, X, and Zhang, L. Thermally induced conformation transition of Triple-Helical Lentinan in NaCl Aqueous Solution. J Physical Chem. 2008; 112:10343-10351.
  2. Poppee, LM et al. Flagellate dermatitis caused by shitake mushrooms. An. Bras. Dermatol. 2012; 87(3):463-465.
  3. Wang, AS, Barr, KL, Jagdeo, J. Shitake mushroom-induced flagellate erythema: A striking case and review of the literature. Dermatol Online J. 2013; 19(4):18174.

AUTHOR CORRESPONDENCE

Milan J. Anadkat MD

E-mail: manadkat@dom.wustl.edu

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