Management of Rosacea-Prone Skin: Evaluation of a Skincare Product Containing Ambophenol, Neurosensine, and La Roche-PosayThermal Spring Water as Monotherapy or Adjunctive Therapy

August 2013 | Volume 12 | Issue 8 | Original Article | 920 | Copyright © August 2013

Sophie Seité PhD,a Florence Benech PharmD,b Sandrine Berdah PhD,b Muriel Bayer PharmD,b Sophie Veyrat PharmD,b Evelyne Segot PharmD PhD,b Marcela Sakalikova Mgr,c Lucia Gibejova Mgr,c Hana Zelenkova MD PhDc

aLa Roche-Posay Pharmaceutical Laboratories, Asnières, France
bL’Oréal Research and Innovation, Chevilly Larue, France
cDOST Svidnik, Private Clinic of Dermatovenerology, Svidnik, Slovakia

Rosacea does not only have a detrimental effect cosmetically, but also leads to a distinct decrease in quality of life which, according to the latest studies, is nonetheless less conspicuous than in the case of atopic eczema, psoriasis or acne.2,9,10 Care must be taken to avoid psychosomatic co-morbidities, such as anxiety and personality disorders. In addition to the visible aspects of this disease, it can have a psychosocial impact that must be evaluated when considering the treatment options. By improving the physical appearance of the skin by reducing erythema, the disabling psychological and social consequences of the condition can be relieved, and patients’ quality of life and confidence improved. In this case the test formula improved not only clinical signs and symptoms and skin reactivity to “trigger factors” but also social, physical, and psychosocial impacts of the disease.
The chronic nature of rosacea and the need for lifelong treatment requires chosen therapies to be effective, safe and well tolerated. Patient education and skincare counseling need to be highlighted as having a major role in the management of this complex and chronic disease. Provision of instructions on skin care and cosmetics to female acne patients influenced quality of life positively compared with a group of patients in which no instructions about make-up were given.21,22 It is likely that these results can be extrapolated to rosacea, in which fewer studies investigating quality of life have been performed. A recent study showed that patient quality of life is improved by make-up in disfiguring skin diseases, including rosacea.23 As ultraviolet light is a recognized trigger for rosacea, patients should use regular applications of a high-factor sunscreen embracing protection against UVB and UVA light wavelengths.


These studies highlight the value of a specifically designed and packaged skincare product containing Ambophenol, Neurosensine, and La Roche-Posay thermal spring water in monotherapy or in combination with or after therapeutic treatment in the global management of patients suffering from rosacea.


These studies were funded by La Roche-Posay Pharmaceutical Laboratories France. All the authors excepted M. Sakalikova, L. Gibejova and H. Zelenkova, are employees of L’Oréal.


Amy Whereat provided proofreading services.


  1. Elewski BE, Draelos Z, Dreno B, Jansen T, Layton A, Picardo M. Rosacea - global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group. J Eur Acad Dermatol Venereol. 2011;25:188-200
  2. Jansen T. Clinical presentations and classification of rosacea. Ann Dermatol Venereol. 2011;138:S138-S147
  3. National Rosacea Society. Rosacea Review Fall.
  4. Berg M, Liden S. An epidemiological study of rosacea. Acta Derm Venereol. 1989;69:419-423.
  5. Sobye P. Aetiology and pathogenesis of rosacea. Acta Derm Venereol. 1950;30:137-158.
  6. Burton JL, Pye RJ, Meyrick G, Shuster S. The sebum secretion rate in rosacea. Br J Dermatol. 1975;92:541-543.
  7. Jansen T, Plewig G, Kligman AM. Acne and Rosacea, 3rd edn. Springer, Berlin, Heidelberg, 2000:456-501.
  8. Wilkin J, Dahl M, Detmar M et al. Standard classification of rosacea: report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol. 2002;46:584-587.
  9. Aksoy B, Altaykan-Hapa A, Egemen D, Karagöz F, Atakan N. The impact of rosacea on quality of life: effects of demographic and clinical characteristics and various treatment modalities. Br J Dermatol. 2010;163(4):719-725.
  10. Gupta MA, Gupta AK, Chen SJ, Johnson AM. Comorbidity of rosacea and depression: an analysis of the National Ambulatory Medical Care Survey and National Hospital Ambulatory Care Survey - Outpatient Department data collected by the U. S. National Center for Health Statistics from 1995 to 2002. >Br J Dermatol. 2005;153:1174-1181.
  11. Kligman AM. A personal critique on the state of knowledge of rosacea. Dermatology. 2004;208:191-197.
  12. Yamasaki K, Di Nardo A, Bardan A et al. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med. 2007;13:975–980.
  13. Schauber J, Gallo RL. Antimicrobial peptides and the skin immune defense system. J Allergy Clin Immunol. 2009;124(3 Suppl. 2):R13–R18.
  14. Forgacs P, Jacquemin H, Moretti C, Provost J, Touche A. Phytochemical studies and biological activities of plants endemic of the islands of Reunion and Mauritius. Plant Med Phytother. 1981;15:80-91.
  15. Lhuillier A. Contribution à l’étude phytochimique de quatre plantes malgaches: Agauria salicifolia Hook.f. ex Oliver, Agauria polyphylla Baker (Ericaceae), Tambourissa trichophylla Baker (Monimiaceae) et Embelia concinna Baker (Myrsinaceae). Les Thèses en ligne de l’lnstitut National Polytechnique de Toulouse (INPT), 2007.
  16. Neergheen VS, Bahorun T, Jen LS, Aruoma Ol. Bioefficacy of Mauritian endemic medicinal plants: assessment of their phenolic Contents and antioxidant potential. Pharm Biol. 2007;45:9-17.
  17. Tamura M, Sebastian S, Gurates B, Yang S, Fang Z, Bulun SE. VEGF up-regulates cyclooxygenase-2 expression in human endothelial cells. J Clin Endocrinol Metab. 2002;87:3504-3507.
  18. Petit V, Seité S. Interest of Ambophenol (Tambourissa extract) in the treatment of rosacea. Poster presented at 21st EADV Congress, Prague, Czech Republic, October 27-30, 2012.
  19. Takagi H, Shiomi H, Ueda H, Amano H. A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser. Nature. 1979;282:410-412.
  20. Seité S. Thermal waters as cosmeceuticals: La Roche-Posay thermal spring water example. Clin Cosmet Invest Derm. 2013;6:1-6.
  21. Matsuoka Y, Yoneda K, Sadahira C, Katsuura J, Moriue T, Kubota Y. Effects of skin care and makeup under instructions from dermatologists on the quality of life of female patients with acne vulgaris. J Dermatol. 2006;33:745-752.
  22. Boehncke WH, Ochsendorf F, Paeslack I et al. Decorative cosmetics improve the quality of life in patients with disfiguring skin diseases. Eur J Dermatol. 2002;12:577-580.
  23. Seité S, Deshayes P, Dréno B et al. Interest of corrective makeup in the management of patients in dermatology. Clin Cosmet Investig Dermatol. 2012;5:123-128.


Sophie Seité