tendency toward more rapid fading, and less frequent conversion from physiological scars to nonphysiological scars when compared
with untreated scars. All scar-specific effects of the scar gel containing extractum cepae, heparin, and allantoin continued to persist after the end of treatment, as demonstrated at follow-up 12 months postsurgery.10 An additional study demonstrated a considerable
difference in scar size in favor of the patients treated with the scar gel containing extractum cepae, heparin, and allantoin compared with the untreated group after 6 to 12 months of treatment.
16 Another randomized, controlled, similarly designed study in children and adolescents aged between 1 and 18 years provides additional support for the efficacy of this treatment. In the group treated with the scar gel containing extractum cepae, heparin, and allantoin, scars were statistically significantly smaller compared with the control group at the 6-month and 12-month observation points, and more postoperative wounds healed into physiological scars.17 Nevertheless, placebo-controlled studies evaluating the ultimate benefit of extractum cepae–containing scar creams are missing, and a recent double-blind study comparing the efficacy between a scar gel containing extractum cepae (Mederma; Merz Pharmaceuticals, Greensboro, NC) and a petrolatum-based emollient
did not reveal any statistically significant differences between the 2 treatment groups in any of the outcome measures studied.25 However, patient numbers were low in this study, and scars varied
in location, origin, and age. Thus, reliable comparison between groups may be difficult in this study.25
The improvements in the parameters measured here support data from other clinical trials and suggest that the scar gel containing extractum cepae, heparin, and allantoin may be effective
for the early treatment of scars arising from a variety of causes. Patients and physicians were very satisfied with the treatment, reporting that it was simple to use, reliable, and well tolerated. This treatment approach may help to prevent excessive
scar formation and, based on data from a large patient cohort, may contribute to physiological scar development. However, more well-designed studies are needed in order to ultimately test the efficacy of the scar gel containing extractum cepae, heparin, and allantoin on prevention of excessive scars and scar maturation.
This article was previously published in German in the journal Kompendium Dermatologie. Editorial support for the resubmission
was provided by Ogilvy 4D, Oxford, UK, and funded by Merz Pharmaceuticals GmbH.
The study was funded by Merz Pharmaceuticals GmbH and Professor
Willital. Professor Willital has received financial support from Merz Pharmaceuticals GmbH for research and consultancy.
Dr. Simon is an employee of Merz Pharmaceuticals GmbH.
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Günter H. Willital MDG.Willital@web.de