hypothesized that low-dose finasteride might negatively influence the DNA integrity of sperm, resulting in increased
pregnancy losses.12 None of these studies described fullterm
pregnancy or live birth during use of or after cessation
of finasteride therapy.
The case reported here describes a spontaneous pregnancy
that occurred 5 months after discontinuation of finasteride
therapy. The pregnancy resulted in a healthy baby, who showed
regular development at age 1 year. Since the patient's semen
quality was unknown before finasteride treatment, this case
cannot support the hypothesis that the effects of finasteride
might be amplified in patients with subfertility.8-10 It cannot
be excluded that semen changes were independent from finasteride administration and that pregnancy was simply
coincidental. However, this case indicates that treatment with
finasteride, even after several years, does not prevent normal
conception. We retain that this observation is relevant because
there are no documented cases of successful pregnancy
currently available in the literature, although millions of men
have taken or are taking finasteride.13
In conclusion, caution should be advised for the use of finasteride
in male partners of couples who trying to conceive.
Furthermore, finasteride discontinuation, particularly in subjects
with impaired semen analysis, should be considered, until
adequate studies are available that report on the drug's effects
of the drug on conception.
The authors have no relevant con!icts of interest to disclose.
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- Mella JM, Perret MC, Manzotti M, Catalano HN, Guyatt G. Efficacy and safety
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- Amory JK, Wang C, Swerdloff RS, et al. The effect of 5alpha-reductase inhibition
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- Lewis RW, Lieber MM, Hellstrom WJ, et al. The effect of finasteride on semen
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- Collodel G, Scapigliati G, Moretti E. Spermatozoa and chronic treatment with
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- Tu HY, Zini A. Finasteride-induced secondary infertility associated with
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