chemical sunscreen)-which aim to prevent the development of further photodamage by minimizing the exposure of
the skin to UV light.
The tolerability of the system was generally good. Only mild adverse events were reported, the most common of
which was facial skin dryness (occurring in 32% of patients). However, it is possible that dryness would occur less frequently in clinical practice when, free from the
constraints of the clinical trial protocol, patients would be able to use a moisturizer as needed.
The investigator evaluations show that the system offers reductions in fine lines and wrinkles, tactile
roughness, intensity of pigmentation, and laxity together with an increase in the lightness/ brightness of the skin. In addition, the patients considered that the system was
easy to apply and resulted in smoother skin, softer skin, more even color tone, more radiant skin, a visible reduction in fine lines and wrinkles, and an improvement in the
overall appearance of their skin.
Overall, the results of this study demonstrate that the prescription strength hydroquinone/L-ascorbic acid
treatment system can be valuable as an early intervention strategy against photodamage in individuals with minimal or mild photodamage and hyperpigmentation. It is also
suitable for patients who are not ready for retinoid therapy or more aggressive anti-aging regimens.
Dr. Bruce has received grants as an investigator for Actavis, Inc., Allergan, Inc., Cipher Pharmaceuticals,
Inc., Contura International A/S, Dow Pharmaceutical Sciences, Inc., Fibrocell Science, Inc., Galderma R & D, Inc., Graceway Pharmaceuticals, LLC, Incyte Corporation, Intendis,
Inc., Isolagen Technologies, Inc., Novartis Pharmaceutical Corporation, Nycomed US, Inc., Obagi Medical Products, Inc., Paddock Laboratories, Inc., Peplin, Inc., Perrigo
Company, Revance Therapeutics, Inc., Schering-Plough Corporation, Solta Medical, Inc., Spear Pharmaceuticals, Inc., Stiefel Laboratories, Inc., Teva Pharmaceuticals, Inc.,
Tolmar, Inc., and Warner Chilcott Ltd. She has also received honoraria as a consultant for Allergan, Inc., Merz Aesthetics, Inc., Obagi Medical Products, Inc., SkinMedica,
Inc., Solta Medical, Inc., and TRIA Beauty, Inc. Dr. Watson is an employee of, and holds stock and stock options in, OMP, Inc.
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competitor formulation. Poster 800 presented at the Summer Academy Meeting 2008 of the American Academy of Dermatology, July 30-August 3, 2008, Chicago, IL.
http://www.aad.org/ElectronicPosters/Posters/ 800/800.pdf. Accessed January 6, 2011.
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- Hughes-Formella BJ, Bohnsack K, Rippke F, et al. Anti-inflammatory effect of hamamelis lotion in a UVB erythema test. Dermatology.
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Address for Correspondence
Suzanne Bruce MD1900 St. James PlaceSuite 600Houston, TX 77056Phone: (713) 796-9199Fax: (713) email@example.com