Oregano Extract Ointment for Wound Healing: A Randomized, Double-Blind, Petrolatum-Controlled Study Evaluating Efficacy

October 2011 | Volume 10 | Issue 10 | Original Article | 1168 | Copyright © October 2011

Jennifer Ragi MD,a Amy Pappert MD,a Babar Rao MD,a Daphna Havkin-Frenkel PhD,b Sandy Milgraum MDa

aDepartment of Dermatology, University Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Somerset, NJ bDepartment of Plant Pathology and Biology, Rutgers University, New Brunswick, NJ

  1. Prystowskiy S, Nonomura J, Smith R, et al. Allergic Hypersensitivity to neomycin: relationship between patch test reactions and use test. Arch Dermatol. 1979; 115:959-962.
  2. Ghadially R, Halkiet-Sorensen L, Elias PM. Effects of Petrolatum on Stratum Corneum Structure and Function. J Am Acad Dermatol. 1992; 26:387-396.
  3. Pinski B. Dressing for dermabrasion: occlusive dressing and wound healing. Cutis 1986; 37(6) 471-6.
  4. Winters GD, Scales JT. Effects of air drying and dressing on the surface of a wound. Nature 1963; 197:91-92.
  5. Leyden JJ, Bartlet NM. Comparison of Topical Antibiotic Ointments as Wound Protectant, and Antiseptics for the Treatment of Human Blister Wounds contaminated with Staphylococcus aureus. J Fam Pract. 1987; 24:601-604.
  6. Dire DJ, Coppola M, Dwyer DA, Lorette JJ, Karr JL. Prospective evaluation of topical antibiotics for preventing infections in uncomplicated soft-tissue wounds repaired in the ED. Acad Emerg Med. 1995; 2(1):4-10.
  7. Berger RS, Pappert AS, Van Zile PS, Cetnarowski WE. A Newly Formulated Topical Triple-Antibiotic Ointment Minimizes Scarring. Cutis. 2000; 65 (6):401-404.
  8. Hood R, Shermock K, Emerman C. A prospective, randomized pilot evaluation of topical triple antibiotic versus mupirocin for the prevention of uncomplicated soft tissue wound infection. Am J Emer Med. 2004; 22 (1):1-4.
  9. Diehr S, Hamp A, Jamiesone B. Do topical antibiotics improve wound healing? J Fam Prac. 2007; 56(2):140-144.
  10. Smack, DP, Harrington AC, et al. Infection and allergy incidence in ambulatory surgery patients using white petrolatum vs bacitracin ointment. JAMA. 1996; 276(12):972-977.
  11. Bigby M. Use of antibiotic ointment after clean cutaneous surgery Arch Dermatol. 2007; 143(9):1180-1182.
  12. Gaynes R. Preserving the effectiveness of antibiotics. JAMA. 2010;303(22):2293-2294.
  13. Wang G, Hindler JF, Ward KW, Bruckner DA. Increased vancomycin MICs for Staphylococcus aureus clinical isolates from a university hospital during a 5-year period. J Clin Microbiol. 2006;44 (11):3883-3886.
  14. Tacconelli E, de Angelis G, Cataldo MA, Pozzi E, Cauda R. Does antibiotic exposure increase the risk of methicillin-resistant Staphylococcus aureus (MRSA) isolation? A systematic review and meta-analysis. J Antimicrob Chemother. 2008; 61(1):26-38.
  15. Rahal JJ, Urban C, Segal-Maurer S. Nosocomial antibiotic resistance in multiple Gram-negative species: experience at one hospital with squeezing the resistance balloon at multiple sites. Clin Infect Dis. 2002; 34(4):499-503.
  16. Baricevic D, Bartol T. The biological/pharmacological activity of the Origanum Genus. In Kintzios SE. Oregano. London and New York: Taylor & Francis; 2002: 177-214.
  17. Nostro A, Blanco AR, Cannatelli MA, et al. Susceptibility of methicillin-resistant staphylococci to oregano essential oil, carvacrol and thymol. FEMS Microbiology Letters. 2004; 230: 191-95.
  18. Mohacsi-farkas, Balogh B, Tulok M. Antimicrobial Activity of greek oregano and winter savory extracts investigated by impedimetry.ISHS Acta Horticulturae 597 International Conference on Medicinal and Aromatic Plants (Part II) 2003.
  19. Friedman, et al. Antimicrobial Wine Formulations Active Against the Foodborne Pathogens Escherichia coli O157: H7 and Salmonella enterica. J Food Science. 2006; 71(7):M245-M251.
  20. Viuda-Marots M, Ruiz-Navajas Y, et al. Antifungal Activities of Thyme, Clove and Oregano Essential Oil. J Food Safety. 2007; 27:91-101.
  21. Eng W, Norman R. Development of an Oregano-based Ointment with Anti-microbial Activity Including activity Against Methicillin-resistant Staphlococcus aureus. J Drugs Dermatol. 2010;9 (4):377-380
  22. Havkin-Frenkel D. (Bakto Natural Preservatives, LLC., US). Recovery of residual plant components after distillation of essential oils. US Patent 0254149 A1, October 16, 2008.
  23. Singletary, K. Oregano Overview of the Literature on Health. Nutr Today. 2010;45(3):129-138.
  24. Hausen, B, Reichling J, Harkenthal M. Degradation products of monterpene are the sensitizing agent in tea tree oil. Am J Cont Derm. 1999; 10(2):68-77
  25. Knight T, Hausen B. Melaleuca oil (tea tree oil) Dermatitis. JAAD. 1994; 30(3):423-427.
  26. Bleasel N, Tate B, Rademaker M. Allergic contact dermatitis following exposure to essential oils. Aust J Dermatol. 2002; 45:211-213.
  27. Trattner A, David M, Lazarov A. Occupational contact dermatitis due to essential oils. Contact Dermatitis. 2008; 58(5):282-284.
  28. Chun S, Vattem D, Lin Y-T, Shetty K. Phenolic antioxidants from clonal oregano (Origanum vulgare) with antimicrobial activity against Helicobacter pylori. Process Biochem. 2005; 40(2):809-816.
  29. Rauha JP, et al. Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds. Intl J Food Microbio. 2000; 56(1):3-12.
  30. Masters M, McMahon M. Reliability Testing of a New Scar Assessment Tool, matching Assessment of Scars and Photographs. J of Burn Care and Rehab. 2005; 26(3)273-283.
  31. Truong PT, Lee JC, et al. Reliability and Validity Testing of the Patient and Observer Scar Assessment Scale in Evaluating Linear Scars after Breast Cancer Surgery. Plastic and Reconstruct Surg. 2007; 119(2):487-494.
  32. Buckingham S. Prevention of Recurrent MRSA Skin Infections: What you Need to Know. Consultant. 2008; 48(13): 1-3.


Jennifer Ragi MDUMDNJ-Robert Wood Johnson Medical SchoolDepartment of Dermatology1 World's Fair DriveSuite 2400Somerset, NJ 08873Phone: (732) 235-7765Fax: (732) 235-7117jenragi@gmail.com