Dimorphic Cutaneous Manifestation of a Toxic Eruption Due to Erlotinib Therapy

December 2008 | Volume 7 | Issue 12 | Case Reports | 1161 | Copyright © December 2008

Tracy M. Campbell MD, Clarence W. Brown Jr MD

Abstract
The epidermal growth factor receptor (EGFR) inhibitor class of agents have been reported to cause multiple cutaneous adverse events. These drug eruptions are thought by some to indicate a good prognosis. The authors report of a case of a psoriasiform scalp eruption simultaneously occurring with an acneiform or follicular rash in a single patient. To present knowledge, this is the first report of a psoriasiform eruption triggered by erlotinib. In addition, this case report demonstrates 2 completely distinct cutaneous morpholo- gies occurring simultaneously with erlotinib therapy in a single patient.