New Onset Flushing due to Unauthorized Substitution of Niacin for Nicotinamide

December 2007 | Volume 6 | Issue 12 | Case Reports | 1220 | Copyright © December 2007

Monique Kademian MD, Mark Bechte MD, Matt Zirwas MD

Abstract
Nicotinamide is the amide form of niacin and has anti-inflammatory properties that have led to its use in the treatment of several inflammatory dermatologic conditions, such as rosacea. Niacin has established its role in the prevention of coronary artery disease. Cutaneous flushing is a well-known and often dose-limiting side effect of niacin therapy, which does not occur with nicotinamide. We report a patient with rosacea who developed new onset flushing due to unauthorized substitution of niacin for nicotinamide. The anti-inflammatory mechanisms of nicotinamide and flushing mechanisms of niacin are discussed.