The First Reported Case of Lichen Planus following Inactivated Influenza Vaccination
May 2007 | Volume 6 | Issue 5 | Case Reports | 536 | Copyright © May 2007
Bengu Nisa Akay MD, Ahu Arslan MD, Saban Cekirge BS, Gul Erkin MD, Rana Anadolu-Brasie MD
Lichen planus (LP) is an idiopathic, inflammatory, pruritic dermatosis of unknown origin. An increased prevalence of a
wide range of diseases such as viral hepatitis C, hepatitis B, primary sclerosing cholangitis, and primary biliary cirrhosis
have been associated with LP. Recently, LP has been reported following administration of different types of hepatis B vaccines
but a relationship with an inactivated influenza vaccine (Fluarix®, GlaxoSmithKline) has not been reported previously.
We present a case of generalized LP manifesting 7 days after the first 0.5-ml dose of influenza vaccine, administered
via deltoid injection. LP is possibly a viral antigen-triggered inflammatory skin condition, the pathogenesis of which needs
to be further explored.