Multivesicular Emulsion: A Novel, Controlled-Release Delivery System for Topical Dermatological Agents

November 2006 | Volume 5 | Issue 10 | Original Article | 942 | Copyright © November 2006

Joseph Bikowski MD, Radhakrishnan Pillai PhD, Braham Shroot PhD

Abstract
Multivesicular emulsion systems are a new patented technology for topical delivery of pharmaceutical and over-the-counter actives. This novel technology involves the creation of a 2-phase, oil-in-water emulsion system that produces concentric multilamellar spheres of oil and water. Active ingredients can be released from their respective layers upon application to the skin. In addition to a controlled-release of active agents, the multivesicular emulsion base improves the biophysical properties of the skin by reducing transepidermal water loss and enhancing skin hydration. This technology has been applied to 6% salicylic acid formulations that in clinical experience show efficacy with high tolerance in several hyperkeratotic disorders. Subjects’ self-assessment was clearly indicative of the excellent cosmetic elegance of the multivesicular emulsion system.