Induction of Lesional and Circulating Leukocyte Apoptosis by Infliximab in a Patient with Moderate to Severe Psoriasis

October 2006 | Volume 5 | Issue 9 | Case Reports | 890 | Copyright © October 2006

Rama Malaviya PhD, Yvonne Sun MD, Jennifer K. Tan BA, Melissa Magliocco MD, Alice B. Gottlieb MD PhD

Abstract
Infliximab demonstrates high efficacy in treating psoriasis in a high proportion of patients. In this report we demonstrate induction of plaque (T cells, dendritic cells) and peripheral blood (T cells, monocytes) leukocyte apoptosis following a single infliximab infusion in a psoriasis patient.