Epidermal Growth Factor Receptor (EGFR) Inhibitor Associated Skin Eruption

April 2006 | Volume 5 | Issue 4 | Case Reports | 368 | Copyright © April 2006

Elizabeth V. Seiverling BS, Emmy M. Fernanadez MD, David Adams MD PharmD

Abstract
EGFR Inhibitors are used to treat Non-Small-Cell Lung Cancer (NSCLC) and colorectal cancer (CRC). A common side effect of EGFR Inhibitors is a follicular/pustular skin eruption. We report a case of gefitinib (Iressa) associated skin eruption. The treatment regimen consisted of triamcinolone 0.1% cream twice daily, clindamycin 1% lotion twice daily and sodium sulfacetamide lotion twice daily. The clinical presentation, etiology, and management options of EGFR Inhibitor associated skin eruptions are discussed.