Bullous Reaction to Topical Methchlorethamine in Mycosis Fungoides
January 2006 | Volume 5 | Issue 1 | Case Reports | 66 | Copyright © January 2006
Jeff Freed MD, Michael Wells MD, Cloyce Stetson MD, Dongwoo Lee MS
Abstract
We describe a patient with mycosis fungoides who developed a bulla shortly after the start of topical methchlorethamine.
Dermal-epidermal separation has been reported to occur with topical methchlorethamine on histological examination.
It is plausible that the compromised dermal-epidermal junction may manifest as a clinical bulla after a secondary insult. To
our knowledge, clinical bulla formation due to topical methchlorethamine has not been reported. 
