Bullous Reaction to Topical Methchlorethamine in Mycosis Fungoides

January 2006 | Volume 5 | Issue 1 | Case Reports | 66 | Copyright © January 2006

Jeff Freed MD, Michael Wells MD, Cloyce Stetson MD, Dongwoo Lee MS

Abstract
We describe a patient with mycosis fungoides who developed a bulla shortly after the start of topical methchlorethamine. Dermal-epidermal separation has been reported to occur with topical methchlorethamine on histological examination. It is plausible that the compromised dermal-epidermal junction may manifest as a clinical bulla after a secondary insult. To our knowledge, clinical bulla formation due to topical methchlorethamine has not been reported.