ABSTRACT: Persistent Grover's disease can cause significant symptoms of pruritus thereby decreasing quality of life. Many patients undergo successful
conservative management of their disease; however, a subset of patients is recalcitrant despite multiple lines of therapy. Accordingly,
we present, to our knowledge, the first reported case of recalcitrant Grover's disease treated successfully with radiotherapy.
J Drugs Dermatol. 2019;18(4):392-393. more
COPY: A number of biologics have been approved for use in plaque-type psoriasis. They act by either blocking the action of a specific
type of cell or protein in the immune system.
CASE PRESENTATION: Herein, we report a case of a 46-year-old woman with a 12-year history of severe plaque psoriasis and psoriatic
arthritis who was treated successfully with guselkumab and adalimumab after failure of prior topical corticosteroids, cyclosporine and
narrow-band ultraviolet B (NBUVB) phototherapy.
CONCLUSION: There is limited data supporting the combination of biological agents in the management of psoriasis and psoriatic arthritis.
This is the ﬁrst case report of plaque psoriasis with arthritis, successfully treated with guselkumab and adalimumab combination
therapy, without concurrent use of other systemic agents during the treatment. However, further studies need to be carried out to
evaluate the efficacy and safety of this biologic combination therapy.
J Drugs Dermatol. 2019;18(4):394-396. more