Objective: To describe patient characteristics, concerns, side effects, treatment satisfaction, and quality of life (QoL) of rosacea patients
currently being treated with monotherapy azelaic acid foam based on patient-reported data.
Methods: The study utilized a non-interventional, prospective, observational design. Patients were recruited in the United States and
were eligible if the following criteria were met: diagnosed with rosacea by a medical professional, ≥18 years of age, currently receiving
monotherapy with azelaic acid foam, and able to provide informed consent. Patients using other topical treatments for rosacea during
enrollment were excluded. An online tool administered a survey of 3 questionnaires including the Rosacea Treatment Preference Questionnaire,
Treatment Satisfaction with Medicines Questionnaire (SATMED-Q), and Dermatology Life Quality Index (DLQI). The survey
collected demographics, clinical characteristics, treatment history, adverse events, and patient-reported outcomes related to treatment
with azelaic acid foam and QoL with rosacea.
Results: 54 patients met eligibility criteria. Participants were primarily female (90.7%), ranging from 26 to 63 years of age. The most
common subtypes reported were erythematotelangiectatic and papulopustular (74.1% each) with 59.3% of participants reporting mild
symptoms (16.7% “absent”; 24.1% “moderate”) in the 4 weeks before enrollment. The majority reported no concerns (74.1%) with
their treatment. The biggest concern was cost (11.1%), with a mean importance score (IS) on a 10-point scale of 9.3. A majority (77.8%)
of patients reported no side effects. Side effects reported included dryness (13%; IS: 5.3), stinging (7.4%, IS: 2.5), itching (5.6%; IS:
4.7), or burning (3.7%; IS: 7.0). Global satisfaction (SATMED-Q) mean score was 79.0 and treatment effectiveness mean score was
70.8. QoL impact of rosacea was minimal (mean DLQI score: 2.35). In regression models, increasing dryness was significantly associated
with worsening outcomes in SATMED-Q and DLQI.
Conclusions: Patient characteristics of the study population closely mirror the distribution of rosacea by gender and subtype as in
previous estimates. Findings indicate minimal patient concerns with azelaic acid foam and primarily pertained to cost. Patient-reported
side effects were rare. Minor patient-reported side effects and concerns do not appear to affect rosacea-related QoL and medication
satisfaction. Compared to a previously conducted study of similar design with patients using metronidazole gel and metronidazole
cream, more patients in the current study reported no concerns with their treatment, while the number of patients reporting no side
effects, as well as mean SATMED-Q and DLQI scores, were similar. Further research is necessary to directly compare the results of
these 2 studies.
J Drugs Dermatol. 2019;18(4):381-386. more