Adapalene/Benzoyl Peroxide Gel 0.3%/2.5%: Effective Acne Therapy Regardless of Age or Gender

June 2017 | Volume 16 | Issue 6 | Original Article | 582 | Copyright © June 2017


Linda Stein Gold MD,a William P. Werschler MD,b Jennifer Mohawk PhDc

aDepartment of Dermatology, Henry Ford Hospital, Detroit, MI bDepartment of Medicine/Dermatology, University of Washington, Seattle, WA cGalderma Laboratories, L.P. Fort Worth, TX

REFERENCES

  1. Tan JK, Bhate K. A global perspective on the epidemiology of acne. Br J Dermatol. Jul 2015;172 Suppl 1:3-12. 
  2. Landis ET, Davis SA, Taheri A, el al. Top dermatologic diagnoses by age. Dermatology Online Journal. 2014;20(4):22368. 
  3. Albuquerque RG, Rocha MA, Bagatin E, et al. Could adult female acne be associated with modern life? Arch Dermatol Res. Oct 2014;306(8):683-688. 
  4. Collier CN, Harper JC, Cafardi JA, et al. The prevalence of acne in adults 20 years and older. J Am Acad Dermatol. Jan 2008;58(1):56-59. 
  5. Ghodsi SZ, Orawa H, Zouboulis CC. Prevalence, severity, and severity risk factors of acne in high school pupils: a community-based study. J Invest Dermatol. Sep 2009;129(9):2136-2141. 
  6. Zeichner JA. Evaluating and treating the adult female patient with acne. J Drugs Dermatol. 2013;12(12):1416-1427. 
  7. Dreno B, Thiboutot D, Layton AM, et al. Large-scale international study enhances understanding of an emerging acne population: adult females. J Eur Acad Dermatol Venereol. Jun 2015;29(6):1096-1106. 
  8. Dreno B. Treatment of adult female acne: a new challenge. J Eur Acad Dermatol Venereol. Jun 2015;29 Suppl 5:14-19. 
  9. Hassan J, Grogan S, Clark-Carter D, et al. The individual health burden of acne: appearance-related distress in male and female adolescents and adults with back, chest and facial acne. J Health Psychol. Nov 2009;14(8):1105-1118. 
  10. Dreno B, Layton A, Zouboulis CC, et al. Adult female acne: a new paradigm. J Eur Acad Dermatol Venereol. Sep 2013;27(9):1063-1070. 
  11. Dreno B, Jean-Decoster C, Georgescu V. Profile of patients with mild-to- moderate acne in Europe: a survey. Eur J Dermatol. Apr 01 2016;26(2):177-184. 
  12. Lynn DD, Umari T, Dunnick CA, et al. The epidemiology of acne vulgaris in late adolescence. Adolesc Health Med Ther. 2016;7:13-25. 
  13. Zaghloul SS, Cunliffe WJ, Good eld MJ. Objective assessment of compliance with treatments in acne. Br J Dermatol. May 2005;152(5):1015-1021. 
  14. Jones-Caballero M, Pedrosa E, Penas PF. Self-reported adherence to treatment and quality of life in mild to moderate acne. Dermatology. 2008;217(4):309-314. 
  15. Lynde C, Tan J, Andriessen A, et al. A consensus on acne management focused on specific patient features. J Cutan Med Surg. Jul-Aug 2014;18(4):243-255. 
  16. Stein Gold L, Weiss J, Rueda MJ, et al. Moderate and Severe Inflammatory Acne Vulgaris Effectively Treated with Single-Agent Therapy by a New Fixed-Dose Combination Adapalene 0.3 %/Benzoyl Peroxide 2.5 % Gel: A Randomized, Double-Blind, Parallel-Group, Controlled Study. Am J Clin. Dermatol. Jun 2016;17(3):293-303. 
  17. Gollnick H, Cunliffe W, Berson D, et al. Management of acne: a report from a Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol. Jul 2003;49(1 Suppl):S1-37. 
  18. Thiboutot D, Gollnick H, Bettoli V, et al. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J Am Acad Dermatol. May 2009;60(5 Suppl):S1-50. 
  19. Thiboutot D, Pariser DM, Egan N, et al. Adapalene gel 0.3% for the treatment of acne vulgaris: a multicenter, randomized, double-blind, controlled, phase III trial. J Am Acad Dermatol. Feb 2006;54(2):242-250. 
  20. Weiss J, Stein Gold L, Leoni M, et al. Customized Single-agent Therapy Management of Severe Inflammatory Acne: A Randomized, Double-blind, Parallel-group, Controlled Study of a New Treatment-- Adapalene 0.3%-Benzoyl Peroxide 2.5% Gel. J Drugs Dermatol. Dec 2015;14(12):1427-1435. 
  21. Pariser DM, Rich P, Cook-Bolden FE, Korotzer A. An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 3.75% for the once-daily treatment of moderate to severe acne vulgaris. J Drugs Dermatol. Sep 2014;13(9):1083-1089. 
  22. Draelos ZD, Carter E, Maloney JM, et al. Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. J Am Acad Dermatol. Mar 2007;56(3):439 e431-410. 
  23. Berg M, Lindberg M. Possible gender differences in the quality of life and choice of therapy in acne. J Eur Acad Dermatol Venereol. Aug 2011;25(8):969-972. 
  24. Motley RJ, Finlay AY. How much disability is caused by acne? Clin Exp Dermatol. May 1989;14(3):194-198. 
  25. Goulden V, Stables GI, Cunliffe WJ. Prevalence of facial acne in adults. J. Am Acad Dermatol. Oct 1999;41(4):577-580. 
  26. Moradi Tuchayi S, Alexander TM, Nadkarni A, et al. Interventions to increase adherence to acne treatment. Patient Prefer Adherence. 2016;10:2091-2096. 
  27. Friedman A, Waite K, Brandt S, Meckfessel MH. Accelerated Onset of Action and Increased Tolerability in Treating Acne With a Fixed-Dose Combination Gel. J Drugs Dermatol. Feb 1 2016;15(2):231-236. 
  28. Patel MLS, Chien AL, Xu H, et al. Improvement in atrophic acne scars by topical adapalene 0.3% gel is associated with induction of procollagen I and III. Society of Investigative Dermatology; 2014; Albuquerque, NM.
  29. Bourdes V. Poster presented at 23rd World Congress of Dermatology, Vancouver, Canada. 2015.
  30. Vega BJ, A.; Michel, S. Regulation of human monocyte toll-like receptor 2 (TLR2) expression by adapalene. J Eur Acad Dermatol Venereol. 2002;16 (Suppl 1):123-124.
  31. Tenaud I, Khammari A, Dreno B. In vitro modulation of TLR-2, CD1d and IL- 10 by adapalene on normal human skin and acne in ammatory lesions. Exp Derm. Jun 2007;16(6):500-506.
  32. Zuliani T, Khammari A, Chaussy H, et al. Ex vivo demonstration of a synergistic effect of Adapalene and benzoyl peroxide on in ammatory acne lesions. Exp Derm. Oct 2011;20(10):850-853.
  33. Stein Gold LB, H.; Rueda, M.J.; Kerrouche, N.; et al. Adapalene-benozyl peroxide gel is efficacious and safe in adult female acne with a profile comparable to that seen in teen-aged females. 2016;9:23-29.