A Retrospective Chart Review of Inflamed Epidermal Inclusion Cysts

February 2021 | Volume 20 | Issue 2 | Editorials | 199 | Copyright © February 2021


Published online December 18, 2020

Harry Meister, Marc Taliercio, Nahla Shihab MD

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY

triamcinolone acetonide, topical anti-infective agents, and oral antibiotics). There were 76 patients from 2016-2019 identified as meeting the criteria required for consideration in the study. No patient reported fever or systemic symptoms. Culture results were identified and sectioned based on the type of bacteria cultured. Courses of treatment were broken down by whether they were antibiotic or non-antibiotic, topical, systemic, intralesional, or surgical (incision and drainage and/ or excision), along with whether they were coupled with other therapies at the time of prescription.

RESULTS

As reflected in Table 1, of the 76 patients with cultures taken of their EIC contents, 36 patients had normal cultures (47%), of whom 19 (25%) had no growth and 17 had growth of normal flora (22%).2 41 positive cultures were identified, including 10 (13%) that grew methicillin-sensitive S. Aureus (MSSA), 6 (8%) that grew methicillin-resistant S. Aureus (MRSA), and 4 (5%) that grew S. Lugdunensis. Finegoldia magna was the most prevalent anaerobic organism found, comprising 3 (4%) of 76 cases. Three (4%) patients were culture positive for Cutibacterium acnes and 1 (1%) for Peptostreptococcus, as would be noted in acne and hidradenitis suppurativa lesions.

As shown in Table 2, treatments prescribed included oral antibiotics: doxycycline (n=25), minocycline (n=13), cephalexin (n=7), amoxicillin-clavulanate (n=2), clindamycin (n=1), and cefdinir (n=1). Twenty-six patients were not initially treated with antibiotics (n=26); eight of these cases turned out to be culture positive lesions- 2 Staphylococcus aureus light/ scant growth, 2 Peptostreptococcus, 1 Staphylococcus aureus with heavy growth, 1 Staphylococcus capitis, 1 Proteus mirabilis, and 1 Strep viridans), by using intralesional triamcinolone acetonide (n=4), incision and drainage (n=6), mupirocin (n=5), and clorhexidine wash (n=1). Four patients required the addition of an oral antibiotic (4 of 41; 10%) based on the bacterial isolates, ie, 50% of the untreated culture positive (4 of 8 cases). Five cases had recurrent symptoms after treatment and 4 were referred for excision. Overall, 16 patients received intralesional triamcinolone acetonide, 25 patients had incision and drainage, 30 received topical therapy (mupirocin, retapamulin or chlorhexidine wash). In the group of 76, only two cases resolved by themselves without prescription or therapies. EIC locations included intertriginous locations (n=19; groin,