A Double-Blind Randomized Controlled Trial Evaluating the Efficacy and Tolerability of a Topical Body Treatment in Combination With Cryolipolysis Procedures

showed impressive reduction of fat tissue on the treated sides. This pilot study and its extensions is extremely encouraging and introduces an exciting potential advancement in an adjuvant topical therapy aiding the outcome of non-invasive procedures.

Alan D. Widgerow is Chief Medical Officer Alastin SkinCare, Carlsbad, CA. Amir Moradi is Consultant and Principal Investigatorfor Alastin, Galderma, Merz, Lutronic; Principal Investigator and honorarium recipient for SkinMedica and Allergan. Jeanette Poehler has no disclosures to report. Alastin products supplied to Moradi office by Alastin SkinCare Inc., Carlsbad, CA.

1. Pinto H, Arredondo E, Ricart-Jane D. Evaluation of adipocytic changes after a simil-lipocryolysis stimulus. Cryo Letters. 2013;34(1):100-5.2. Ingargiola MJ, Motakef S, Chung MT, Vasconez HC, Sasaki GH. Cryolipolysis for fat reduction and body contouring: safety and efficacy of current treatment paradigms. Plast Reconstr Surg. 2015;135(6):1581-90.3. Ferraro GA, De Francesco F, Cataldo C, Rossano F, Nicoletti G, D'Andrea F. Synergistic effects of cryolipolysis and shock waves for noninvasive body contouring. Aesthetic Plast Surg. 2012;36(3):666-79.4. Kwon TR, Yoo KH, Oh CT, et al. Improved methods for selective cryolipolysis results in subcutaneous fat layer reduction in a porcine model. Skin Res Technol. 2015; 21(2):192-200.5. Grant RW, Stephens JM. Fat in flames: influence of cytokines and pattern recognition receptors on adipocyte lipolysis. Am J Physiol Endocrinol Metab. 2015;309(3):E205-13.6. Gregory CD, Devitt A. The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically? Immunology. 2004;113(1):1-14.7. Maixner N, Kovsan J, Harman-Boehm I, Bluher M, Bashan N, Rudich A. Autophagy in adipose tissue. Obes Facts. 2012;5(5):710-21.8. Wang CW. Lipid droplets, lipophagy, and beyond. Biochim Biophys Acta. 2016;1861(8 Pt B):793-805.