In Vivo Reflectance Confocal Microscopy Features of Discoid Lupus Erythematosus

September 2012 | Volume 11 | Issue 9 | Case Report | 1111 | Copyright © 2012

Abstract

Background: Discoid lupus erythematosus (DLE) is an inflammatory condition characterized by round demarcated lesions with varying amounts of erythema, telangiectasia, scaling, follicular plugging, dyspigmentation, atrophy, and scarring. Clinical diagnosis can be confirmed through biopsy samples; reflectance confocal microscopy (RCM) is also emerging as an accurate diagnostic tool.
Objective and Methods:Our objective was to examine the features of discoid lupus erythematosus on reflectance confocal microscopy. Two patients presenting with discoid lupus erythematosus were imaged using RCM. Features seen in RCM were correlated with those seen in histopathology.
Results:Reflectance confocal microscopy images of discoid lupus erythematosus yielded features characteristically seen in histopathological samples including inflammatory cells, inflammation at the dermo-epidermal junction, pigment incontinence, and vacuolar degeneration.
Conclusion:Reflectance confocal microscopy is a useful tool in the diagnosis of discoid lupus erythematosus. Features described in these two cases as well as prior research have yielded sufficient data to allow for the formulation of useful RCM diagnostic algorithms. Further studies with a larger patient population will help in confirming and describing new features of DLE on RCM.

J Drugs Dermatol. 2012;11(9):1111-1113.

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INTRODUCTION

Discoid lupus erythematosus (DLE) is a subtype of lupus erythematosus which presents mainly in areas above the neck include the nose, malar region, and ears.1 It is characterized clinically by round demarcated lesions with varying degrees of erythema, telangiectasia, scaling, follicular plugging, dyspigmentation, atrophy, and scarring.2 While clinical presentation is usually distinctive enough to diagnose DLE, histopathological samples may be needed to differentiate it from chronic eczema, toxicity reactions from prior treatment, sarcoidosis, light eruptions, lymphomas and pseudolymphomas, and postinflammatory hyperpigmentation.1,2

An alternative to the traditional biopsy for the confirmation of a DLE diagnosis is reflectance confocal microscopy (RCM), a noninvasive imaging tool that uses infrared light to illuminate the underlying skin and reflects these images back through an aperture, which then allows for the assembly of black and white images in a confocal plane.3 The white contrast is provided by various highly refractive structures such as melanin, inflammatory cells, and other skin structures.4,5 Optically layered sections of the skin down to the level of 300 μm or the superficial dermis can be captured by RCM. Reflectance confocal microscopy provides a 3-dimensional view of the imaged lesion through horizontal plane imaging, which provides a section similar to histology and the vertical plane imaging.6

CASE SERIES

Case 1

A 47 year-old African-American female presented with a hyper-pigmented, erythematous plaque on her right cheek (figure 1) for which the differential diagnosis clinically was DLE vs post-inflammatory hyperpigmentation. The lesion on RCM (Vivascope 1500, Lucid Inc., Rochester, NY) showed features consistent with DLE including inflammatory cells, (Figure 2), inflammation at the dermo-epidermal junctions (Figure 3), and vacuolar degeneration (Figures 4 and 5), a biopsy from the lesion revealed areas of vacuolar degeneration and pigment incontinence consistent with the RCM diagnosis of DLE (Figure 6).

Case 2

A 50 year-old female patient with history of DLE diagnosed in 2009 presented in July 2011 with a 15-mm irregularly shaped plaque on her right lateral cheek. Her initial diagnosis of DLE in 2009 had been made from a papule on her nose; she also presented at the time with patchy alopecia and a lesion on her scalp. After a year-long treatment regimen of topical steroids and other care for DLE such as avoiding the sun and using sunscreen, her lesions were healed. Prior to biopsy of her new lesion in July 2011, the lesion was imaged with RCM. Areas of vacuolar degeneration with inflammation at dermo-epidermal junction (Figure 7) were observed in the RCM images. Biopsy of this new lesion confirmed the clinical and RCM diagnoses

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