Evaluation of the Chemopreventative Effects of ALA PDT in Patients With Multiple Actinic Keratoses and a History of Skin Cancer
May 2012 | Volume 11 | Issue 5 | Original Article | 593 | Copyright © 2012
Background: Actinic keratoses (AKs) are in situ epidermal tumors that may progress to invasive squamous cell carcinomas (SCCs). Aminolevulinic acid with photodynamic therapy (ALA PDT) is a field treatment for AK.
Objective: To evaluate the time to development of new non-melanoma skin cancers (NMSC) within one year of ALA-PDT treatment in immunocompetent patients with AK and a history of skin cancer.
Methods and Materials: One hundred forty anatomic sites in 114 patients were treated with topical ALA for a 1 to 3 hour incubation period followed by photodynamic therapy (PDT) with a blue light. All new NMSCs within the treatment areas were recorded over a 1-year observational period.
Results: Eighty-three anatomic sites (59%) did not develop new skin cancers within 1 year. Additionally, 92%, 78%, and 64% of anatomic sites were free of new skin cancers at 3, 6, and 9 months after treatment was initiated. Although approximately 41% of patients treated on both the scalp and face developed new skin cancers within 1 year of treatment, the average time to develop skin cancer was longer for the face (7.09 months) than for the scalp (5.34 months).
Conclusion: In patients with a history of NMSC and multiple AKs, ALA PDT may be a valuable option for the prevention and delay of new NMSCs.
J Drugs Dermatol. 2012;11(5):593-597.
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Discrete actinic keratoses (AKs) may be treated by cryosurgery with liquid nitrogen, curettage with electrodessication, topical creams (imiquimod, 5-fluorouracil, diclofenac), or surgery; however, targeted therapeutic modalities are not as effective for widespread and subclinical lesions. In 1999, photodynamic therapy (PDT) with topical aminolevulinic acid (ALA) was approved by the FDA for treatment of AKs on the face and scalp.1-3 ALA PDT indiscriminately treats an entire area of skin, allowing for management not only of discrete lesions, but also subclinical ones.3-15 Here we report the presentation of new skin cancers in patients with a history of NMSC and AKs 1 year after treatment with ALA PDT.
METHODS AND MATERIALS