Successful Treatment of Perniosis With Hydroxychloroquine

October 2010 | Volume 9 | Issue 10 | Original Article | 1242 | Copyright © 2010

Xiao Yang MD, Oliver A. Perez MD, Joseph C. English III MD

Abstract

Background: The current medical therapies for perniosis are diverse. The agents used have produced variable results and lack evidence-based data. Objective: To determine outcomes of patients with perniosis treated with hydroxychloroquine. Methods: In this retrospective study, patients with a diagnosis of perniosis treated with hydroxychloroquine were analyzed for dosage required, subjective improvement in signs and symptoms, and adverse drug reactions. Results: Hydroxychloroquine resulted in improvement of symptoms in four of five patients. Review of the literature has revealed 12 out of 51 cases have responded to hydroxychloroquine alone or in combination with other therapies. Conclusion: Hydroxychloroquine is a relatively safe, well tolerated alternative therapy for the treatment of perniosis and should be considered as part of the initial management. Additional data are needed to further evaluate this drug in a prospective manner and in a larger population of patients.

Purchase Original Article

Purchase a single fully formatted PDF of the original manuscript as it was published in the JDD.

Download the original manuscript as it was published in the JDD.

Contact a member of the JDD Sales Team to request a quote or purchase bulk reprints, e-prints or international translation requests.

To get access to JDD's full-text articles and archives, upgrade here.

Save an unformatted copy of this article for on-screen viewing.

Print the full-text of article as it appears on the JDD site.

→ proceed | ↑ close

Related Articles