Nanoparticles: A Closer Look at Their Dermal Effects

May 2010 | Volume 9 | Issue 5 | Original Article | 475 | Copyright © 2010

Adrienne N. Choksi MD, Tasneem Poonawalla MD, Michael G. Wilkerson MD


Nano-sized particles represent a unique class of materials with novel physiochemical properties due to increased surface area. Many sunscreens and cosmetics are now using nano-sized titanium dioxide and zinc oxide, which avoids the white, chalky appearance of the older preparations. Although the U.S. Food and Drug Administration (FDA) has determined that nano-sized titanium dioxide is not a new ingredient, but a specific grade of the original product, recent studies suggest that nanomaterials products may not be equivalent to their respective bulk-form products, and the adverse effects of nanoparticles cannot be reliably predicted from the properties of the material in bulk form. Nanoparticles are incorporated into a variety of skin care products, and in the future may be useful as transdermal drug delivery devices. Thus, understanding potential epidermal and dermal penetration, as well as possible toxicity, is important to the field of dermatology. The authors present a review of the therapeutic applications and potential toxicity of nanoparticles relevant to the field of dermatology thus far.

Purchase Original Article

Purchase a single fully formatted PDF of the original manuscript as it was published in the JDD.

Download the original manuscript as it was published in the JDD.

Contact a member of the JDD Sales Team to request a quote or purchase bulk reprints, e-prints or international translation requests.

To get access to JDD's full-text articles and archives, upgrade here.

Save an unformatted copy of this article for on-screen viewing.

Print the full-text of article as it appears on the JDD site.

→ proceed | ↑ close

Related Articles