Hair Growth in Patients With Alopecia Areata Totalis After TreatmentWith Simvatatin and Ezetimibe
January 2009 | Volume 9 | Issue 1 | Case Report | 62 | Copyright © 2009
Asra Ali MD and John M. Martin IV MD
Alopecia areata is an autoimmune disorder characterized by the sudden development of a circumscribed patch of nonscarring hair loss on the scalp or any hair-bearing surface. The presentation of this disorder can be hair loss in a single circumscribed patch, complete loss of hair on the scalp (alopecia totalis) or complete loss of hair on the entire body (alopecia universalis). The following cases involve two patients with treatment-refractory alopecias that benefited significantly after treatment with a combination of ezetimibe and simvastatin, in addition to the continuation of intra-lesional corticosteroid injections. In this report, the known immunomodulatory effects of statins in combination with ezetimibe are discussed along with the known histopathologic findings of autoimmune alopecia. Major histocompatibility complex class II (MHC-II) and intracellular adhesion molecule-1(ICAM-1) appear to be involved in both the immunomodulatory effects of statins and the pathophysiology of autoimmune alopecia.
Purchase Original Article
Purchase a single fully formatted PDF of the original manuscript as it was published in the JDD.
Download the original manuscript as it was published in the JDD.
Contact a member of the JDD Sales Team to request a quote or purchase bulk reprints, e-prints or international translation requests.
To get access to JDD's full-text articles and archives, upgrade here.
Save an unformatted copy of this article for on-screen viewing.
Print the full-text of article as it appears on the JDD site.→ proceed | ↑ close