Delayed Presentation of Impending Necrosis following Soft Tissue Augmentation with Hyaluronic Acid and Successful Management with Hyaluronidase

March 2007 | Volume 6 | Issue 3 | Case Report | 325 | Copyright © 2007

Ranella J. Hirsch MD FAAD, Mary Lupo MD FAAD, Joel L. Cohen MD FAAD, David Duffy MD FAAD


Soft tissue augmentation is a key element in the successful management of facial rhytids and scars. Injection of hyaluronic acid gels into the dermis is generally well-tolerated with only minimal side effects. Injection necrosis is a rare but clinically significant side effect.1,2 We present a case of what appears to be slow swelling after injection of Juvederm™ (Allergan, Irvine, CA), which yielded delayed compression and vascular occlusion resulting in cutaneous necrosis. Such vascular compromise can present as delayed rather than immediately upon injection as would be the case with similarly reported cases of intra-arterial injection.

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