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Polidocanol, a popular sclerosant used to treat unwanted leg veins worldwide, was approved by the U.S. Food and Drug Administration (FDA) in March of 2010. This new treatment option joins popular sclerosant formulas including sodium tetradecylsulfate, hypertonic saline and chromated glycerin. Evidence for the efficacy of polidocanol, its efficacy relative to other sclerosants and its safety profile is reviewed.

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