JDDonline.com

July 2010

859

VOLUME 9 • ISSUE 7

Warfarin-induced Skin Necrosis Mimicking Calciphylaxis: A Case Report and Review of the Literature

Abstract

Warfarin-induced skin necrosis (WISN) and calciphylaxis share similar early clinical findings and can both lead to significant morbidity and mortality. The authors reviewed the literature on both conditions and describe a case of extensive skin necrosis in a patient with end-stage renal disease who was initially suspected to have calciphylaxis. Further investigation supported a diagnosis of WISN. The pathogenesis, clinical manifestations and treatment of WISN and calciphylaxis are discussed, with emphasis on a diagnostic approach for early recognition.

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