March 2010 |
273 |
VOLUME 9 • ISSUE 3 |
Copyright © 2010 |
Case Report |
Journal of Drugs in Dermatology |
March 2010 |
273 |
VOLUME 9 • ISSUE 3 |
Copyright © 2010 |
Case Report |
Journal of Drugs in Dermatology |
Generalized Necrobiotic Xanthogranuloma Successfully Treated With Lenalidomide
Abstract
Necrobiotic xanthogranuloma (NXG) presents a therapeutic challenge to clinicians. Generalized NXG has limited treatment options. A
patient presented to the authors with generalized NXG associated with monoclonal gammopathy of unknown significance (MGUS),
a plasma cell dyscrasia considered to be a precursor to multiple myeloma.
The patient was treated with lenalidomide, a derivative of thalidomide with efficacy in treatment of multiple myeloma. Resolution of
paraproteinemia was associated with resolution of NXG.