ABSTRACT: Acne scarring can affect patients across the spectrum of acne severity. Of multiple potential risk factors, the most important is acne severity followed by time to effective treatment, manipulation of lesions, and a family history of acne scarring.2 These factors reflect the intensity and duration of inflammation as well as an intrinsic tendency to scar. more
ABSTRACT: Acne is a common disease affecting a high percentage of the younger population. Without appropriate and effective primary prevention of scarring, post-acne scars occur in about 80-95% of all patients. Acne scarring is the result of an alteration of the healing process and it can have deep psychosocial implications for patients. Scars can involve textural change in the superficial and deep dermis and it can also be associated with erythema or pigmentation. While the most effective strategy to reduce acne scarring is to prevent its formation, over the past decades, numerous aesthetic and surgical techniques have been proposed to improve the appearance of acne scarring. However, scar treatment still remains suboptimal; indeed, acne scarring management is a difficult therapeutic challenge for dermatologists. Several treatment options have been described to treat various acne scar types and clinical responses may differ from various factors, such as skin types. Treatment approaches for acne scarring should be individualized and primarily determined by the morphological features of each patient’s scars. Dermatologists need to better organize their assessment of acne scarring and develop a multistep treatment plans tailored to address patients’ individual needs.
J Drugs Dermatol. 2018;17(12 Suppl):s44-48 more
ABSTRACT: Acne vulgaris is the most common skin condition affecting adolescents and young adults with a tremendous psychosocial impact. Its pathogenic hallmarks include follicular dyskeratosis, increased sebum production, and inflammation induced by Cutibacterium (formerly Propionibacterium) acnes within the follicle. Retinoids, derived from vitamin A, are the mainstays of acne treatment given they address the key pathogenic pathways of acne. Retinoids exert their effects through the binding of their nuclear receptors leading to downstream biological effects. The understanding of retinoid pharmacology has increased the diversity of retinoids with now both natural and synthetic retinoids available for use. For acne, retinoids can be administered both topically in a variety of formulations and combinations as well as systemically. With judicious use, this class of medication is well tolerated and very efficacious in managing acne. Furthermore, there is evidence showing its role in improving and preventing one of the most challenging post-acne changes, atrophic acne scarring. With a promising topical retinoid, trifarotene, on the horizon, the acne armamentarium will be further broadened to better manage acne and its related sequelae.
J Drugs Dermatol. 2018;17(12 Suppl):s51-55 more