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Title:	Familial Pityriasis Rubra Pilaris: Report of a Family and Therapeutic Response to Etanercept
Author:	Marie Vasher MD, Erica Smithberger MD, Mary H. Lien MD, Neil Alan Fenske MD
Abstract:	Pityriasis rubra pilaris (PRP) is an uncommon dermatosis of unknown etiology. The familial subtype is rare and usually presents as type V PRP. It is generally inherited in an autosomal dominant fashion with variable expression. Other forms of inheritance, such as autosomal recessive and X-linked, have also been reported. The use of etanercept in treating resistant forms of PRP is promising given reports of its success in a few cases. Herein, the authors report two cases of PRP arising in a mother and son and review the rare familial subtype of this disease. In addition, a successful therapeutic trial of etanercept was initiated in the mother based on case reports of its efficacy in other patients with PRP.
Section:	Case Report
Year:	2010
Volume:	9
Issue:	7
Page:	844
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