Debbie M. Palmer DO and Jennifer Silverman Kitchin MD
It is believed that oxidative stress is caused by an imbalance between the production of reactive oxygen and a biological system’s
ability to neutralize the reactive intermediates. Oxidative damage occurs because of both intrinsic and extrinsic mechanisms. Together,
intrinsic and extrinsic damage are the primary causes of skin aging. The skin uses a series of intrinsic antioxidants to protect
itself from free radical damage. Naturally occurring extrinsic antioxidants have also been widely shown to offset and alleviate these
changes. Unlike sunscreens, which have an SPF rating system to guide consumers in their purchases, there is no widely accepted
method to choose antioxidant anti-aging products. ORAC (Oxygen Radical Absorbance Capacity) and ABEL-RAC (Analysis By Emitted
Light-Relative Antioxidant Capacity), are both accepted worldwide as a standard measure of the antioxidant capacity of foods, and are
rating systems that could be applied to all antioxidant skincare products. The standardization of antioxidant creams could revolutionize
the cosmeceutical market and give physicians and consumers the ability to compare and choose effectively
Dvora Ancona MD and Bruce E. Katz MD
Background and Objective: The purpose of this study was to assess the efficacy and safety of a new fractional CO2 laser system
for improving periorbital rhytids, tightening skin and elevating the eyebrow.
Materials and Methods: One hundred subjects with periocular wrinkles, tissue laxity, photoaged skin and moderate dermatochalasis
of the face were prospectively treated one to four times in the periorbital area with a fractional CO2 laser device equipped with a
scanning handpiece. Improvements in eyelid wrinkles, crow’s feet and skin laxity were evaluated photographically by two blinded,
independent observers. Eyebrow elevation was measured by the investigators. Subjects also scored satisfaction and tolerability.
Results: Approximately half of subjects achieved or maintained 26–50% improvement at 12 months. Nearly 40% of subjects maintained
1–2 mm elevation of the brow at six and 12 months after treatment. Subject satisfaction was high and the procedure was well
tolerated. Mild-to-moderate erythema and edema persisted for up to three to four days.
Conclusion: Treatment with a fractional CO2 laser device improves periorbital rhytids, tightens skin and elevates the eyebrow with
minimal adverse effects.
Mitchel P. Goldman MD and Michael H. Gold MD
Purpose: To determine the efficacy of a skin care system developed with a partially neutralized glycolic compound and natural antioxidants
when compared to Cetaphil moisturizing regimen for the treatment of photoaging of the face, eye and mouth.
Methods: A total of 36 patients between 35 and 65 years of age were randomized on a 3:1 ratio to use either Vivité Skin Care System
or Cetaphil cleanser and moisturizer for 60 days. Facial skin was evaluated at baseline, day 30 and day 60. Subjects were required to
fill out a self-evaluation of facial skin quality before, during, and after treatment. Investigators evaluated facial wrinkling using a common
wrinkling scale as well as a visual evaluation of skin texture in a masked manner.
Results: A similar proportion of patients in each group had a 1-point improvement on the hyperpigmentation scale (42% of Vivité patients,
44% of Cetaphil patients). There were no statistically significant between-group differences in investigator rating of wrinkles.
Subjectively, patients preferred Vivité to Cetaphil for noticeable improvement in fine lines or wrinkles (37.6–0%, respectively) at the
first follow-up. By the final follow-up, more than half the patients in the Vivité group continued to notice an improvement in fine lines
or wrinkles, compared with fewer than 25% in the Cetaphil group. More than twice the number of patients in the Vivité group noticed
improvement in skin elasticity or tightness compared with those in the Cetaphil group.
Conclusion: Patients reported that the Vivité skin care system improved the appearance of wrinkling and improved skin texture associated
with moderate photoaging of the face, eye and mouth areas. Vivité had a higher patient preference rating than a commonly
used moisturizing regimen. There were no differences noted in the physician evaluations.
The standard of care for the treatment of depression involves pharmacologic therapy with selective serotonin reuptake inhibitors
(SSRIs). Cognitive therapy is typically utilized in addition to a pharmacologic intervention. However, the benefits of the drugs used
may be marginal compared with placebo yet the costs associated with their use continue to increase. One potential treatment for
depression utilizes botulinum toxins. At the present time there is a small body of evidence supporting their use for depression, the
potential efficacy and cost effectiveness of this treatment warrants further consideration including head to head clinical trials.
Alan B. Fleischer Jr. MD, Alan Shalita MD, Lawrence F. Eichenfield MD, William Abramovits MD,Anne Lucky MD, Steven Garrett DDS, for the Dapsone Gel in Combination Treatment Study Group
Purpose: To evaluate the safety and efficacy of dapsone gel 5% in the treatment of acne when used in combination with adapalene
gel 0.1%, benzoyl peroxide gel 4% or moisturizer.
Methods: This was a twelve-week, randomized, double-blind study. Patients aged 12 years and older (n=301) applied dapsone gel
twice daily and were randomly assigned (1:1:1) to one of three additional treatments, applied once daily.
Results: By week 12, dapsone gel combined with any of the three additional treatments reduced the mean number of inflammatory
lesions. However, the authors did not detect a significant difference in the reduction of inflammatory lesions when dapsone
was used in combination with adapalene gel or with benzoyl peroxide gel compared to the dapsone plus moisturizer combination
group (P=0.052 for both versus moisturizer combination). Patients treated with dapsone gel combined with adapalene showed a
significantly better response in reduction in non-inflammatory and total acne lesion count than those who received the moisturizer
combination. Local adverse reactions in all three treatment groups were minimal and generally mild in severity.
Conclusion: Dapsone gel in combination with adapalene gel or benzoyl peroxide gel is safe and well tolerated for the treatment of
Scalp lesions are common among patients with psoriasis, seborrheic dermatitis and a number of other inflammatory and fungal conditions.
Topical corticosteroids are a mainstay of treatment for many scalp dermatoses and they significantly reduce erythema, scaling
and pruritus. Conventional corticosteroid formulations such as cream and ointments are often difficult or time consuming for patients
to apply and may produce undesirable cosmetic effects. Medicated shampoos provide a more convenient alternative for patients
who require topical administration of corticosteroids for scalp conditions. Tar shampoos have long been used to treat psoriasis and
are effective for the long-term maintenance of remission in patients who respond to therapy. Antifungal shampoos are effective
for the treatment of seborrheic dermatitis and other mycotic conditions. A shampoo formulation containing fluocinolone acetonide,
0.01% is also approved for the treatment of seborrheic dermatitis. One superpotent corticosteroid shampoo (clobetasol propionate
0.05%; Clobex® Shampoo) is approved in the United States (U.S.) for once-daily treatment of psoriasis of the scalp. The results of a
2007 pilot study also demonstrated that clobetasol propionate shampoo improved the signs and symptoms of seborrheic dermatitis.
These findings suggest that high-potency corticosteroid shampoos may provide an important option for topical corticosteroid therapy
in dermatologic conditions affecting the scalp
Timothy J. Falla PhD and Lijuan Zhang PhD
Due to a reduction in estrogen levels peri- and post-menopausal skin exhibit a specific phenotype characterized by reduced thickness,
reduced elasticity and increased dryness. Loss of these elements results in increased skin wrinkling and skin sagging. In addition, it
is well documented that reduced estrogen levels also negatively impacts dermal wound healing. As a result we tested the hypothesis
that molecules capable of stimulating and accelerating wound healing can supplement the skin’s diminished activities produced
by reduced estrogen. Heptapeptide-7, a fragment of a well-characterized wound healing peptide (HB-107), was found to stimulate
keratinocyte proliferation and migration and induce collagen synthesis. Microarray analysis of Heptapeptide-7-treated dermal keratinocytes
revealed an up-regulation of cell division, growth factor and extracellular matrix genes. Validation of this approach was seen
in a clinical study of 32 women (mean age 54) in which forehead wrinkles and skin texture were improved with the application of this
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No abstract details for the moment.
No abstract details for the moment.